GNRH1 and GNRHR

Data Source:
HPRD (in vivo)

		GNRH1	GNRHR
Description		gonadotropin releasing hormone 1	gonadotropin releasing hormone receptor
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Mitochondrion Golgi-associated Vesicle Dendrite Perikaryon Axon Terminus Cytoplasmic Side Of Rough Endoplasmic Reticulum Membrane Neurosecretory Vesicle	Plasma Membrane Integral Component Of Plasma Membrane Membrane
	Molecular Function	Hormone Activity Gonadotropin Hormone-releasing Hormone Activity Gonadotropin-releasing Hormone Receptor Binding	G Protein-coupled Receptor Activity Gonadotropin-releasing Hormone Receptor Activity Peptide Binding
	Biological Process	Reproduction Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Multicellular Organism Development Female Pregnancy Aging Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Male Sex Determination Response To Corticosteroid Response To Lipopolysaccharide Negative Regulation Of Immature T Cell Proliferation Response To Testosterone Response To Prostaglandin E Response To Potassium Ion Negative Regulation Of Apoptotic Process Estrous Cycle Response To Ethanol Response To Prolactin Regulation Of Ovarian Follicle Development Negative Regulation Of Neuron Migration	G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development Cellular Response To Gonadotropin-releasing Hormone
Pathways		Hormone ligand-binding receptors G alpha (q) signalling events	Hormone ligand-binding receptors G alpha (q) signalling events
Drugs			Leuprolide Goserelin Cetrorelix Abarelix Gonadorelin Nafarelin Danazol Teverelix Sufugolix Degarelix Buserelin Ganirelix Histrelin Triptorelin Gestrinone Relugolix Elagolix
Diseases			Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
GWAS		Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Length of menstrual cycle ( 30202859) Menopause (age at onset) ( 29773799) Metabolite levels ( 23823483) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Regular attendance at a pub or social club ( 29970889)
Interacting Genes		2 interacting genes: GNRHR MEP1A	5 interacting genes: GNRH1 GPAA1 RGS10 TMEM161A TSPAN7
Entrez ID		2796	2798
HPRD ID		08860	00732
Ensembl ID		ENSG00000147437	ENSG00000109163
Uniprot IDs		P01148	P30968
PDB IDs		4D5M	7BR3
Enriched GO Terms of Interacting Partners?
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