GNAO1 and OPRD1

Data Source:
HPRD (in vivo)

		GNAO1	OPRD1
Description		G protein subunit alpha o1	opioid receptor delta 1
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GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Dendrite Myelin Sheath Cell Body	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Synaptic Vesicle Membrane Intrinsic Component Of Plasma Membrane Dendrite Membrane Neuron Projection Axon Terminus Membrane Raft Spine Apparatus Neuronal Dense Core Vesicle Integral Component Of Presynaptic Membrane Integral Component Of Postsynaptic Density Membrane
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding GTPase Activating Protein Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	G Protein-coupled Receptor Activity Opioid Receptor Activity Protein Binding Receptor Serine/threonine Kinase Binding Enkephalin Receptor Activity Peptide Binding Neuropeptide Binding
	Biological Process	Protein Folding Muscle Contraction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Aging Locomotory Behavior Regulation Of Heart Contraction Forebrain Development Neuron Projection Development Response To Cytokine Odontogenesis Of Dentin-containing Tooth Response To Drug Response To Hydrogen Peroxide Response To Morphine Positive Regulation Of GTPase Activity Negative Regulation Of Calcium Ion Transport	Immune Response G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Adult Locomotory Behavior Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Opioid Receptor Signaling Pathway Eating Behavior Regulation Of Mitochondrial Membrane Potential Regulation Of Calcium Ion Transport Regulation Of Sensory Perception Of Pain Cellular Response To Growth Factor Stimulus Cellular Response To Hypoxia Cellular Response To Toxic Substance
Pathways		PLC beta mediated events PLC beta mediated events G-protein activation Ca2+ pathway Ca2+ pathway Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Peptide ligand-binding receptors G alpha (i) signalling events Interleukin-4 and Interleukin-13 signaling
Drugs			Tramadol Morphine Codeine Amitriptyline Hydromorphone Methadone Oxycodone Dextromethorphan Butorphanol Dextropropoxyphene Naltrexone Sufentanil Fentanyl Loperamide Nalbuphine Levorphanol Remifentanil Buprenorphine Hydrocodone Diphenoxylate Naloxone Oxymorphone Ketamine Aripiprazole 3-Methylthiofentanyl Dimethylthiambutene Diamorphine Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl ADL5859 Tapentadol Nalmefene Alvimopan Morphine glucuronide Ketobemidone Cannabidiol Butyrfentanyl Pholcodine Eluxadoline Opium Naldemedine Metenkefalin Medical Cannabis Nabiximols Loxicodegol
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Cardioembolic stroke (CCSp classification) ( 32047268) Chronotype ( 30696823) Diastolic blood pressure ( 30578418) Dimensional psychopathology (Positive) ( 29496196) HDL cholesterol levels ( 32203549) Metabolite levels ( 23823483) Mitochondrial DNA copy number ( 30704525) Morning person ( 30696823) Pulse pressure ( 27841878) Sleep duration (short sleep) ( 30846698)	Tourette syndrome ( 30818990)
Interacting Genes		34 interacting genes: ADORA1 ADRA2A ADRA2C CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR	22 interacting genes: ADRB2 ARRB1 ARRB2 CTXN3 GNA15 GNAI1 GNAI2 GNAO1 GNAZ GPRASP1 GRK2 KLHL3 OPRK1 OPRM1 PRKCA PRKCD PRKCE RPRM SLC12A7 SLC13A4 SMAGP TMEM237
Entrez ID		2775	4985
HPRD ID		00757	01308
Ensembl ID		ENSG00000087258	ENSG00000116329
Uniprot IDs		B3KP89 P09471 Q6AWC5 Q8N6I9	P41143
PDB IDs		6FUF 6G79 6K41 6OIK 6WWZ	1OZC 2IQM 4N6H 4RWA 4RWD 6PT2 6PT3
Enriched GO Terms of Interacting Partners?
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