GNAO1 and NUCB1

Data Source:
HPRD (in vitro, two hybrid)

		GNAO1	NUCB1
Description		G protein subunit alpha o1	nucleobindin 1
Image
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Dendrite Myelin Sheath Cell Body	Extracellular Space Nucleus Early Endosome Endoplasmic Reticulum Lumen Rough Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi-associated Vesicle Cis-Golgi Network Trans-Golgi Network Membrane Golgi Cisterna Membrane Extracellular Exosome Extrinsic Component Of Golgi Membrane Lumenal Side Of Golgi Membrane
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding GTPase Activating Protein Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	G-protein Alpha-subunit Binding DNA Binding Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding
	Biological Process	Protein Folding Muscle Contraction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Aging Locomotory Behavior Regulation Of Heart Contraction Forebrain Development Neuron Projection Development Response To Cytokine Odontogenesis Of Dentin-containing Tooth Response To Drug Response To Hydrogen Peroxide Response To Morphine Positive Regulation Of GTPase Activity Negative Regulation Of Calcium Ion Transport	Small GTPase Mediated Signal Transduction Post-translational Protein Modification Cellular Protein Metabolic Process Regulation Of Catalytic Activity Response To Cisplatin Regulation Of Protein Targeting
Pathways		PLC beta mediated events PLC beta mediated events G-protein activation Ca2+ pathway Ca2+ pathway Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Cardioembolic stroke (CCSp classification) ( 32047268) Chronotype ( 30696823) Diastolic blood pressure ( 30578418) Dimensional psychopathology (Positive) ( 29496196) HDL cholesterol levels ( 32203549) Metabolite levels ( 23823483) Mitochondrial DNA copy number ( 30704525) Morning person ( 30696823) Pulse pressure ( 27841878) Sleep duration (short sleep) ( 30846698)
Interacting Genes		34 interacting genes: ADORA1 ADRA2A ADRA2C CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR	16 interacting genes: GNAI1 GNAI2 GNAI3 GNAO1 GNAS GNAZ HIVEP1 MYC NDN PTGS1 PTGS2 RBL1 REL SET SIRPA XPO1
Entrez ID		2775	4924
HPRD ID		00757	03205
Ensembl ID		ENSG00000087258	ENSG00000104805
Uniprot IDs		B3KP89 P09471 Q6AWC5 Q8N6I9	A8K7Q1 Q02818
PDB IDs		6FUF 6G79 6K41 6OIK 6WWZ	1SNL
Enriched GO Terms of Interacting Partners?
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