GNAO1 and ADRA2C

Data Source:
HPRD (in vivo)

		GNAO1	ADRA2C
Description		G protein subunit alpha o1	adrenoceptor alpha 2C
Image
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Dendrite Myelin Sheath Cell Body	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane Neuronal Cell Body Axon Terminus Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding GTPase Activating Protein Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	G Protein-coupled Receptor Activity Alpha2-adrenergic Receptor Activity Protein Binding Alpha-2A Adrenergic Receptor Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Epinephrine Binding
	Biological Process	Protein Folding Muscle Contraction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Aging Locomotory Behavior Regulation Of Heart Contraction Forebrain Development Neuron Projection Development Response To Cytokine Odontogenesis Of Dentin-containing Tooth Response To Drug Response To Hydrogen Peroxide Response To Morphine Positive Regulation Of GTPase Activity Negative Regulation Of Calcium Ion Transport	G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Female Pregnancy Negative Regulation Of Norepinephrine Secretion Platelet Activation Activation Of Protein Kinase B Activity Negative Regulation Of Epinephrine Secretion Receptor Transactivation Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Differentiation Positive Regulation Of Vasoconstriction Regulation Of Insulin Secretion Regulation Of Sensory Perception Of Pain Negative Regulation Of Uterine Smooth Muscle Contraction Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Pathways		PLC beta mediated events PLC beta mediated events G-protein activation Ca2+ pathway Ca2+ pathway Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Adrenoceptors Adrenaline signalling through Alpha-2 adrenergic receptor Adrenaline,noradrenaline inhibits insulin secretion G alpha (i) signalling events G alpha (z) signalling events Surfactant metabolism
Drugs			Amphetamine Tramadol Bethanidine Ziprasidone Cabergoline Ropinirole Clozapine Norepinephrine Phenylpropanolamine Loxapine Prochlorperazine Chlorpromazine Brimonidine Haloperidol Nortriptyline Amoxapine Clonidine Lisuride Ergotamine Tizanidine Apomorphine Paroxetine Risperidone Tolazoline Fenoldopam Phenoxybenzamine Maprotiline Oxymetazoline Ergoloid mesylate Promethazine Carvedilol Desipramine Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Ephedra sinica root Mephentermine Yohimbine Methotrimeprazine Dextroamphetamine Metamfetamine Celiprolol Dronedarone Iloperidone OPC-28326 Epicept NP-1 Mianserin Pizotifen Asenapine Ocaperidone Droxidopa Esmirtazapine Xylometazoline Levonordefrin Lurasidone Agmatine Brexpiprazole Dosulepin Etoperidone Lorpiprazole Cirazoline Moxisylyte Aranidipine Setiptiline Racepinephrine Dihydroergocornine DL-Methylephedrine Xylazine Indigotindisulfonic acid Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Cardioembolic stroke (CCSp classification) ( 32047268) Chronotype ( 30696823) Diastolic blood pressure ( 30578418) Dimensional psychopathology (Positive) ( 29496196) HDL cholesterol levels ( 32203549) Metabolite levels ( 23823483) Mitochondrial DNA copy number ( 30704525) Morning person ( 30696823) Pulse pressure ( 27841878) Sleep duration (short sleep) ( 30846698)	Blood urea nitrogen levels ( 31152163) Lung cancer in ever smokers ( 28604730) Nickel levels ( 26025379) Urinary potassium excretion ( 31409800)
Interacting Genes		34 interacting genes: ADORA1 ADRA2A ADRA2C CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR	17 interacting genes: CCDC24 CHCHD2 CNPY2 EIF2B1 GNAO1 HGS KLHL38 KRT34 MDFI MEIS2 MGAT5B MKRN3 P4HA3 PPP1R9B UCHL1 WWOX YWHAZ
Entrez ID		2775	152
HPRD ID		00757	00085
Ensembl ID		ENSG00000087258	ENSG00000184160
Uniprot IDs		B3KP89 P09471 Q6AWC5 Q8N6I9	P18825 Q4W594
PDB IDs		6FUF 6G79 6K41 6OIK 6WWZ	6KUW
Enriched GO Terms of Interacting Partners?
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