GNA11 and RGS3

Data Source:
HPRD (in vitro, in vivo)

		GNA11	RGS3
Description		G protein subunit alpha 11	regulator of G protein signaling 3
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Synapse Extracellular Exosome	Nucleus Cytosol Plasma Membrane
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding	GTPase Activity GTPase Activator Activity Protein Binding
	Biological Process	Skeletal System Development Action Potential Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Heart Development Phototransduction, Visible Light Entrainment Of Circadian Clock Platelet Activation Regulation Of Melanocyte Differentiation Developmental Pigmentation Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To PH	Inactivation Of MAPK Activity Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity
Pathways		Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs)	G alpha (q) signalling events G alpha (i) signalling events
Drugs
Diseases
GWAS		Asthma ( 31959851)	Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Red blood cell count ( 32888494) Refractive error ( 32231278)
Interacting Genes		17 interacting genes: ADRA1B ADRB2 BDKRB2 CHRM2 EDNRA EDNRB HTR2A HTR2B KDR MTNR1A PTGIR RGS14 RGS3 SLC9A3R1 TBXA2R TRPC3 TSHR	24 interacting genes: ACD APP CNKSR2 CYSRT1 DEPDC1B EFNB1 EFNB2 ESR1 GLS2 GNA11 GNAI3 GORASP2 GRIN2A HES4 HIPK3 MAPK12 PAX6 PLSCR1 PRKN SCN5A YWHAB YWHAE YWHAQ YWHAZ
Entrez ID		2767	5998
HPRD ID		00759	03720
Ensembl ID		ENSG00000088256	ENSG00000138835
Uniprot IDs		P29992	A0A024R831 A0A024R833 A0A024R841 B3KVT7 B3KWG8 H7BXY1 P49796 Q53GP3
PDB IDs		6OIJ	2F5Y 2OJ4 3FBK
Enriched GO Terms of Interacting Partners?
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