GNA11 and EDNRA

Data Source:
HPRD (in vitro)

		GNA11	EDNRA
Description		G protein subunit alpha 11	endothelin receptor type A
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Synapse Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding	Phosphatidylinositol Phospholipase C Activity Endothelin Receptor Activity Protein Binding
	Biological Process	Skeletal System Development Action Potential Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Heart Development Phototransduction, Visible Light Entrainment Of Circadian Clock Platelet Activation Regulation Of Melanocyte Differentiation Developmental Pigmentation Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To PH	Branching Involved In Blood Vessel Morphogenesis Response To Hypoxia In Utero Embryonic Development Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Heart Development Respiratory Gaseous Exchange By Respiratory System Regulation Of Blood Pressure Cell Population Proliferation Regulation Of Glucose Transmembrane Transport Neural Crest Cell Development Artery Smooth Muscle Contraction Vasoconstriction Enteric Nervous System Development Head Development Endothelin Receptor Signaling Pathway
Pathways		Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs)	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs			Bosentan Acetylsalicylic acid 2-HYDROXY-3,5-DIIODOBENZOIC ACID Darusentan SPP 301 Actelion-1 Atrasentan Sitaxentan Ambrisentan Enrasentan Tezosentan Clazosentan Macitentan Sparsentan
Diseases
GWAS		Asthma ( 31959851)	Carotid intima media thickness ( 21909108) Carotid plaque ( 30510157) Coronary artery disease ( 32469254 29212778 24262325 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or large artery stroke ( 24262325) Dental caries ( 23064961) Intracranial aneurysm ( 22286173) Ischemic stroke (large artery atherosclerosis) ( 29531354) Lead levels ( 26025379) Myocardial infarction ( 26343387) Obesity-related traits ( 23251661) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042) Peripheral artery disease ( 26488411 31285632) Plasma clusterin levels ( 26545630) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Resting heart rate ( 27798624) Serum bilirubin levels x Mediterranean diet adherence interaction in metabolic syndrome ( 30621171) Systolic blood pressure ( 27841878)
Interacting Genes		17 interacting genes: ADRA1B ADRB2 BDKRB2 CHRM2 EDNRA EDNRB HTR2A HTR2B KDR MTNR1A PTGIR RGS14 RGS3 SLC9A3R1 TBXA2R TRPC3 TSHR	7 interacting genes: EDN1 EDN3 GNA11 GNAI2 GRK6 HDAC7 KAT5
Entrez ID		2767	1909
HPRD ID		00759	00571
Ensembl ID		ENSG00000088256	ENSG00000151617
Uniprot IDs		P29992	P25101
PDB IDs		6OIJ
Enriched GO Terms of Interacting Partners?
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