RGS3 and GNAI3

Data Source:
HPRD (in vivo)

		RGS3	GNAI3
Description		regulator of G protein signaling 3	G protein subunit alpha i3
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GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane	Golgi Membrane Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Centrosome Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Zymogen Granule Membrane Raft Extracellular Exosome
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding GTPase Activating Protein Binding Metal Ion Binding
	Biological Process	Inactivation Of MAPK Activity Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity	Protein Folding Vesicle Fusion Cell Cycle G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Dopamine Receptor Signaling Pathway Brain Development Positive Regulation Of Macroautophagy Positive Regulation Of Superoxide Anion Generation Positive Regulation Of NAD(P)H Oxidase Activity GTP Metabolic Process Cell Division Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Apoptotic Signaling Pathway
Pathways		G alpha (q) signalling events G alpha (i) signalling events	PLC beta mediated events PLC beta mediated events Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G-protein activation ADP signalling through P2Y purinoceptor 12 G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases
GWAS		Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Red blood cell count ( 32888494) Refractive error ( 32231278)	Childhood body mass index ( 33045005) Major depressive disorder ( 20125088)
Interacting Genes		24 interacting genes: ACD APP CNKSR2 CYSRT1 DEPDC1B EFNB1 EFNB2 ESR1 GLS2 GNA11 GNAI3 GORASP2 GRIN2A HES4 HIPK3 MAPK12 PAX6 PLSCR1 PRKN SCN5A YWHAB YWHAE YWHAQ YWHAZ	43 interacting genes: AGTR2 ATP12A CCDC88A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 GNB2 GNB4 GPSM1 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PCP2 PHF24 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SOX30 TSHR
Entrez ID		5998	2773
HPRD ID		03720	00765
Ensembl ID		ENSG00000138835	ENSG00000065135
Uniprot IDs		A0A024R831 A0A024R833 A0A024R841 B3KVT7 B3KWG8 H7BXY1 P49796 Q53GP3	P08754
PDB IDs		2F5Y 2OJ4 3FBK	2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S
Enriched GO Terms of Interacting Partners?
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