EDNRA and GRK6

Data Source:
HPRD (in vitro)

		EDNRA	GRK6
Description		endothelin receptor type A	G protein-coupled receptor kinase 6
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Plasma Membrane Membrane
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Endothelin Receptor Activity Protein Binding	G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Beta-adrenergic Receptor Kinase Activity
	Biological Process	Branching Involved In Blood Vessel Morphogenesis Response To Hypoxia In Utero Embryonic Development Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Heart Development Respiratory Gaseous Exchange By Respiratory System Regulation Of Blood Pressure Cell Population Proliferation Regulation Of Glucose Transmembrane Transport Neural Crest Cell Development Artery Smooth Muscle Contraction Vasoconstriction Enteric Nervous System Development Head Development Endothelin Receptor Signaling Pathway	Protein Phosphorylation G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	G alpha (s) signalling events
Drugs		Bosentan Acetylsalicylic acid 2-HYDROXY-3,5-DIIODOBENZOIC ACID Darusentan SPP 301 Actelion-1 Atrasentan Sitaxentan Ambrisentan Enrasentan Tezosentan Clazosentan Macitentan Sparsentan
Diseases
GWAS		Carotid intima media thickness ( 21909108) Carotid plaque ( 30510157) Coronary artery disease ( 32469254 29212778 24262325 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or large artery stroke ( 24262325) Dental caries ( 23064961) Intracranial aneurysm ( 22286173) Ischemic stroke (large artery atherosclerosis) ( 29531354) Lead levels ( 26025379) Myocardial infarction ( 26343387) Obesity-related traits ( 23251661) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042) Peripheral artery disease ( 26488411 31285632) Plasma clusterin levels ( 26545630) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Resting heart rate ( 27798624) Serum bilirubin levels x Mediterranean diet adherence interaction in metabolic syndrome ( 30621171) Systolic blood pressure ( 27841878)	Activated partial thromboplastin time ( 22703881) Blood protein levels ( 28240269) Cardiac troponin-I levels ( 31014085) Chronic kidney disease ( 20383146) Extremely high intelligence ( 29520040) Glycine levels ( 30837465) Intelligence (MTAG) ( 29326435) Metabolite levels ( 22916037) Neutrophil percentage of white cells ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		7 interacting genes: EDN1 EDN3 GNA11 GNAI2 GRK6 HDAC7 KAT5	19 interacting genes: ADRB2 BDKRB2 CHRM3 EDNRA EDNRB FBXO7 FSHR GIT1 ITGA5 KCNIP3 LTB4R PRSS23 RCVRN RHO SLC9A3R1 SNCA SNCB SNCG TBXA2R
Entrez ID		1909	2870
HPRD ID		00571	02925
Ensembl ID		ENSG00000151617	ENSG00000198055
Uniprot IDs		P25101	B3KPS5 P43250
PDB IDs			2ACX 3NYN 3NYO
Enriched GO Terms of Interacting Partners?
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