GLI3 and STK36

Data Source:
HPRD (in vivo)

		GLI3	STK36
Description		GLI family zinc finger 3	serine/threonine kinase 36
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cilium Axoneme Nuclear Speck Transcription Repressor Complex Intracellular Membrane-bounded Organelle Ciliary Tip Ciliary Base	Extracellular Region Nucleus Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Histone Acetyltransferase Binding Mediator Complex Binding Histone Deacetylase Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Metanephros Development Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Positive Regulation Of Neuroblast Proliferation Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Axon Guidance Hindgut Morphogenesis Heart Development Negative Regulation Of Cell Population Proliferation Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Protein Processing Optic Nerve Morphogenesis Hippocampus Development Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Forebrain Dorsal/ventral Pattern Formation Layer Formation In Cerebral Cortex Forebrain Radial Glial Cell Differentiation Lateral Ganglionic Eminence Cell Proliferation Melanocyte Differentiation Lung Development Prostate Gland Development Positive Regulation Of Chondrocyte Differentiation T Cell Differentiation In Thymus Limb Morphogenesis Wound Healing Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Nose Morphogenesis Tongue Development Response To Estrogen Negative Thymic T Cell Selection Negative Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Embryonic Digestive Tract Morphogenesis Embryonic Digestive Tract Development Developmental Growth Camera-type Eye Morphogenesis Embryonic Neurocranium Morphogenesis Oligodendrocyte Differentiation Roof Of Mouth Development Frontal Suture Morphogenesis Lambdoid Suture Morphogenesis Sagittal Suture Morphogenesis Mammary Gland Specification Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Artery Development Anterior Semicircular Canal Development Lateral Semicircular Canal Development Cell Differentiation Involved In Kidney Development Thymocyte Apoptotic Process Vocalization Behavior Negative Regulation Of Canonical Wnt Signaling Pathway Liver Regeneration Larynx Morphogenesis Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Regulation Of Bone Development	Epithelial Cilium Movement Involved In Extracellular Fluid Movement Protein Phosphorylation Smoothened Signaling Pathway Positive Regulation Of Hh Target Transcription Factor Activity Brain Development Post-embryonic Development Positive Regulation Of Smoothened Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Cilium Assembly
Pathways		GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state Hedgehog 'on' state GLI proteins bind promoters of Hh responsive genes to promote transcription RUNX2 regulates osteoblast differentiation
Drugs			Fostamatinib
Diseases		Pallister-Hall syndrome Acrocallosal syndrome; Greig cephalopolysyndactyly syndrome
GWAS		Age-related macular degeneration ( 23326517) Allergic rhinitis ( 22036096) Asthma ( 29273806) Dietary fat liking ( 32516399) Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Emotional recognition ( 31596458) facial morphology traits (multivariate analysis) ( 27193062) Health literacy ( 31250787) Language performance in older adults (adjusted for episodic memory) ( 28577822) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Metabolite levels ( 23823483) middle facial morphology traits (quantitative measurement) ( 27193062) Refractive error ( 32231278)	Amyotrophic lateral sclerosis ( 22959728) Hematocrit ( 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Male-pattern baldness ( 28196072) Red blood cell count ( 32888494) Refractive error ( 32231278)
Interacting Genes		19 interacting genes: BTRC CREBBP CSNK1A1 GSK3A MED12 PRKCA RHOU SKI SMAD1 SMAD2 SMAD3 SMAD4 STK36 SUFU TAF9 TWIST1 ZIC1 ZIC2 ZIC3	10 interacting genes: CDK5RAP2 CDK9 CLNK FRMPD4 GLI1 GLI2 GLI3 MAST2 MID1 SUFU
Entrez ID		2737	27148
HPRD ID		01313	09631
Ensembl ID		ENSG00000106571	ENSG00000163482
Uniprot IDs		A0A2R8YGX0 P10071	A0A140VJW1 Q9NRP7
PDB IDs		4BLD
Enriched GO Terms of Interacting Partners?
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