TNRC6A and TRIM65

Data Source:
BioGRID (enzymatic study)

		TNRC6A	TRIM65
Description		trinucleotide repeat containing adaptor 6A	tripartite motif containing 65
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleoplasm Golgi Apparatus Cytosol RISC Complex Intracellular Membrane-bounded Organelle	Nucleoplasm Cytosol
	Molecular Function	RNA Binding Protein Binding	Zinc Ion Binding
	Biological Process	Wnt Signaling Pathway, Calcium Modulating Pathway Cellular Response To Starvation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Post-transcriptional Gene Silencing By RNA Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Gene Silencing By MiRNA	Positive Regulation Of Autophagy
Pathways		Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Post-transcriptional silencing by small RNAs Transcriptional regulation by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases
GWAS		Adult body size ( 32376654) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258 30679032) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Experiencing mood swings ( 29500382) General cognitive ability ( 29844566) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Macular thickness ( 30535121) Mean platelet volume ( 32888494) Metabolic syndrome ( 31589552) Problematic alcohol use ( 32451486) Pulse pressure ( 27841878 27618448 30578418) Systolic blood pressure ( 27841878 27618448 30578418) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)	Body mass index ( 29273807) Deep white matter hyperintensities ( 32517579) Psoriasis ( 28537254) Reticulocyte count ( 32888494) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 21681796 25663218) White matter hyperintensity volume ( 30659137)
Interacting Genes		7 interacting genes: AGO4 PAN2 SMARCB1 TRIM65 TRIP13 UBC WNK1	12 interacting genes: ANAPC11 IFIH1 MARCHF7 MKRN3 RBCK1 SRPK1 TNRC6A UBE2D2 UBE2U UBE2Z UBE3A VCAM1
Entrez ID		27327	201292
HPRD ID		11640	15569
Ensembl ID		ENSG00000090905	ENSG00000141569
Uniprot IDs		Q8NDV7	Q6PJ69
PDB IDs		5W6V
Enriched GO Terms of Interacting Partners?
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