TRIM65 and RBCK1

Data Source:
BioGRID (two hybrid)

		TRIM65	RBCK1
Description		tripartite motif containing 65	RANBP2-type and C3HC4-type zinc finger containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol	Ubiquitin Ligase Complex Cytosol LUBAC Complex
	Molecular Function	Zinc Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Identical Protein Binding Ubiquitin Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Autophagy	Protein Polyubiquitination I-kappaB Kinase/NF-kappaB Signaling Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Viral Process Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Protein Linear Polyubiquitination Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Body mass index ( 29273807) Deep white matter hyperintensities ( 32517579) Psoriasis ( 28537254) Reticulocyte count ( 32888494) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 21681796 25663218) White matter hyperintensity volume ( 30659137)	Night sleep phenotypes ( 27126917)
Interacting Genes		12 interacting genes: ANAPC11 IFIH1 MARCHF7 MKRN3 RBCK1 SRPK1 TNRC6A UBE2D2 UBE2U UBE2Z UBE3A VCAM1	65 interacting genes: APP ARNT2 BACH1 CREB5 CREBBP ENKD1 GLYCTK HGS HOXA1 HOXC8 IL16 IREB2 KANK2 LNX1 MALT1 MAP3K1 MAPKBP1 MKRN2 NAA10 NDUFAF3 NEDD4 NR1I2 OTUB2 OTUD6A PAN2 PCGF2 PRKCA PRKN PSMA1 PSMD4 RNF181 RNF31 SMURF1 SOCS6 SYCE1 TNFAIP3 TP53 TRAF1 TRIM21 TRIM25 TRIM65 TRIML1 TSSK3 TTC23 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2K UBE2L3 UBE2L6 UBE2N UBE2S UBE2U UCHL5 UHRF2 USP15 USP2 USP21 USP32 USP49 USP7 ZNF414
Entrez ID		201292	10616
HPRD ID		15569	16643
Ensembl ID		ENSG00000141569	ENSG00000125826
Uniprot IDs		Q6PJ69	A6PVJ6 A6PVK0 Q9BYM8
PDB IDs			2CRC 2LGY 4DBG
Enriched GO Terms of Interacting Partners?
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