TRIM65 and TNRC6A

Data Source:
BioGRID (enzymatic study)

		TRIM65	TNRC6A
Description		tripartite motif containing 65	trinucleotide repeat containing adaptor 6A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol	P-body Nucleoplasm Golgi Apparatus Cytosol RISC Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Zinc Ion Binding	RNA Binding Protein Binding
	Biological Process	Positive Regulation Of Autophagy	Wnt Signaling Pathway, Calcium Modulating Pathway Cellular Response To Starvation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Post-transcriptional Gene Silencing By RNA Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Gene Silencing By MiRNA
Pathways			Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Post-transcriptional silencing by small RNAs Transcriptional regulation by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases
GWAS		Body mass index ( 29273807) Deep white matter hyperintensities ( 32517579) Psoriasis ( 28537254) Reticulocyte count ( 32888494) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 21681796 25663218) White matter hyperintensity volume ( 30659137)	Adult body size ( 32376654) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258 30679032) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Experiencing mood swings ( 29500382) General cognitive ability ( 29844566) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Macular thickness ( 30535121) Mean platelet volume ( 32888494) Metabolic syndrome ( 31589552) Problematic alcohol use ( 32451486) Pulse pressure ( 27841878 27618448 30578418) Systolic blood pressure ( 27841878 27618448 30578418) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)
Interacting Genes		12 interacting genes: ANAPC11 IFIH1 MARCHF7 MKRN3 RBCK1 SRPK1 TNRC6A UBE2D2 UBE2U UBE2Z UBE3A VCAM1	7 interacting genes: AGO4 PAN2 SMARCB1 TRIM65 TRIP13 UBC WNK1
Entrez ID		201292	27327
HPRD ID		15569	11640
Ensembl ID		ENSG00000141569	ENSG00000090905
Uniprot IDs		Q6PJ69	Q8NDV7
PDB IDs			5W6V
Enriched GO Terms of Interacting Partners?
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