GCLM and OSGIN1

Data Source:
BioGRID (two hybrid)

		GCLM	OSGIN1
Description		glutamate-cysteine ligase modifier subunit	oxidative stress induced growth inhibitor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Glutamate-cysteine Ligase Complex	Cellular_component
	Molecular Function	Glutamate-cysteine Ligase Activity Protein Binding Enzyme Regulator Activity Glutamate-cysteine Ligase Catalytic Subunit Binding Protein-containing Complex Binding	Protein Binding Growth Factor Activity
	Biological Process	Cysteine Metabolic Process Glutamate Metabolic Process Glutathione Biosynthetic Process Response To Oxidative Stress Aging Response To Nutrient Apoptotic Mitochondrial Changes Response To Activity Positive Regulation Of Glutamate-cysteine Ligase Activity Cellular Response To Hepatocyte Growth Factor Stimulus Hepatic Stellate Cell Activation Response To Drug Negative Regulation Of Neuron Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Human Chorionic Gonadotropin Response To Nitrosative Stress Regulation Of Mitochondrial Depolarization Cellular Response To Glucose Stimulus Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Thyroxine Stimulus Blood Vessel Diameter Maintenance Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Signal Transduction Multicellular Organism Development Cell Differentiation Negative Regulation Of Cell Growth Regulation Of Cell Migration Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process
Pathways		Glutathione synthesis and recycling Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
Drugs		Glutamic acid Cysteine
Diseases
GWAS		Metabolite levels ( 23823483) Ovarian cancer ( 30557369) Refractive error ( 32231278) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	LDL cholesterol ( 30275531) Pursuit maintenance gain ( 29064472) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872)
Interacting Genes		4 interacting genes: CALM1 IRF7 OSGIN1 STOX1	47 interacting genes: AKT1 ARNT2 ATM BCAR3 BEND7 BTBD2 CAPN3 CCDC33 CENPN CRX DECR2 DNAJA3 FGFR4 GCLM HOMEZ IKBKG IKZF3 INCA1 KATNBL1 KRAS KRT75 LNX1 MEI4 MEIS2 MEOX1 MEOX2 MTERF4 PAX5 PDE4A PDE4C PICK1 POLDIP3 POLR2G PPM1D PTEN REL SAXO1 SMARCB1 SORBS3 TCF12 TCF4 TLE5 TRIM54 XRCC3 ZBTB42 ZC2HC1C ZKSCAN4
Entrez ID		2730	29948
HPRD ID		03106	06412
Ensembl ID		ENSG00000023909	ENSG00000140961
Uniprot IDs		P48507	Q9UJX0
PDB IDs
Enriched GO Terms of Interacting Partners?
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