GCLM

Description		glutamate-cysteine ligase modifier subunit
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Glutamate-cysteine Ligase Complex
	Molecular Function	Glutamate-cysteine Ligase Activity Protein Binding Enzyme Regulator Activity Glutamate-cysteine Ligase Catalytic Subunit Binding Protein-containing Complex Binding
	Biological Process	Cysteine Metabolic Process Glutamate Metabolic Process Glutathione Biosynthetic Process Response To Oxidative Stress Aging Response To Nutrient Apoptotic Mitochondrial Changes Response To Activity Positive Regulation Of Glutamate-cysteine Ligase Activity Cellular Response To Hepatocyte Growth Factor Stimulus Hepatic Stellate Cell Activation Response To Drug Negative Regulation Of Neuron Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Human Chorionic Gonadotropin Response To Nitrosative Stress Regulation Of Mitochondrial Depolarization Cellular Response To Glucose Stimulus Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Thyroxine Stimulus Blood Vessel Diameter Maintenance Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Glutathione synthesis and recycling Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
Drugs		Glutamic acid Cysteine
Diseases
GWAS		Metabolite levels ( 23823483) Ovarian cancer ( 30557369) Refractive error ( 32231278) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		4 interacting genes: CALM1 IRF7 OSGIN1 STOX1
Entrez ID		2730
HPRD ID		03106
Ensembl ID		ENSG00000023909
Uniprot IDs		P48507
PDB IDs
Enriched GO Terms of Interacting Partners?
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