GCLM and STOX1

Data Source:
BioGRID (two hybrid)

		GCLM	STOX1
Description		glutamate-cysteine ligase modifier subunit	storkhead box 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Glutamate-cysteine Ligase Complex	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol
	Molecular Function	Glutamate-cysteine Ligase Activity Protein Binding Enzyme Regulator Activity Glutamate-cysteine Ligase Catalytic Subunit Binding Protein-containing Complex Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding
	Biological Process	Cysteine Metabolic Process Glutamate Metabolic Process Glutathione Biosynthetic Process Response To Oxidative Stress Aging Response To Nutrient Apoptotic Mitochondrial Changes Response To Activity Positive Regulation Of Glutamate-cysteine Ligase Activity Cellular Response To Hepatocyte Growth Factor Stimulus Hepatic Stellate Cell Activation Response To Drug Negative Regulation Of Neuron Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Human Chorionic Gonadotropin Response To Nitrosative Stress Regulation Of Mitochondrial Depolarization Cellular Response To Glucose Stimulus Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Thyroxine Stimulus Blood Vessel Diameter Maintenance Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Cell Cycle Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Mitochondrion Organization Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Peptidyl-serine Phosphorylation Cell Division Regulation Of Mitochondrial Membrane Potential Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Nitrosative Stress Regulation Of Mitochondrial DNA Metabolic Process Regulation Of Response To Oxidative Stress Positive Regulation Of Cyclin-dependent Protein Kinase Activity
Pathways		Glutathione synthesis and recycling Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
Drugs		Glutamic acid Cysteine
Diseases
GWAS		Metabolite levels ( 23823483) Ovarian cancer ( 30557369) Refractive error ( 32231278) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Amyotrophic lateral sclerosis (sporadic) ( 24529757)
Interacting Genes		4 interacting genes: CALM1 IRF7 OSGIN1 STOX1	7 interacting genes: ADARB1 BANP GCLM GORASP2 NFYC POU2F1 ROR2
Entrez ID		2730	219736
HPRD ID		03106	18579
Ensembl ID		ENSG00000023909	ENSG00000165730
Uniprot IDs		P48507	Q6ZVD7
PDB IDs
Enriched GO Terms of Interacting Partners?
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