VENTX and SPRY4

Data Source:
BioGRID (two hybrid)

		VENTX	SPRY4
Description		VENT homeobox	sprouty RTK signaling antagonist 4
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Cytoplasm Cytosol Focal Adhesion Ruffle Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Protein Kinase Inhibitor Activity Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Negative Regulation Of Ras Protein Signal Transduction Animal Organ Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Senescence-Associated Secretory Phenotype (SASP) Transcriptional Regulation by VENTX
Drugs
Diseases
GWAS			Asthma ( 31959851 29273806) Body mass index ( 28552196) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Gut microbiota (bacterial taxa) ( 27723756) Height ( 31562340) Inflammatory bowel disease ( 23128233) Physiological traits ( 31902109) Systolic blood pressure ( 30578418) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 19483681 28604728 28604732 23666239 23666240)
Interacting Genes		93 interacting genes: ABHD11 ADAMTSL4 ARID5A ARSA ATXN7L1 BATF2 BHLHE40 C10orf55 C19orf54 C1orf94 C6orf15 CEACAM6 CERCAM CES1 CFP CREM CSN3 CTAG1A CTAG1B CYSRT1 DAB1 DAZAP2 FAM168B FAM86C1P GLIS2 HOXC8 HYPK INTS11 IRF9 ITIH6 KRT34 KRTAP10-8 KRTAP11-1 KRTAP12-2 KRTAP12-4 KRTAP13-1 KRTAP19-1 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP22-1 KRTAP26-1 KRTAP3-1 KRTAP3-3 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LITAF LYG1 MAGED1 MIEN1 ODAM PLA2G2F PLEKHB1 POU6F2 PRR20A PRR20B PRR20C PRR20D PRR20E RBFOX1 RBPMS RHOXF2 RNF144B RNF4 ROR2 RSKR SLC15A2 SMUG1 SOX14 SPRY4 SYNGAP1 TBX15 TBX19 TBX22 TEKT5 TLE2 TMBIM4 TMEM42 TRIP13 TSC1 UBAP2 UBE2I UBQLN2 USP54 VAC14 VHLL WWOX YPEL3 ZBTB32 ZNF34	17 interacting genes: ADAM12 COL8A1 CREB5 EFEMP2 FHL2 HOXA1 KLHL38 KRTAP5-11 NUTF2 OTX1 POU4F2 RAF1 RIN3 TESK1 TNS2 VENTX ZDHHC17
Entrez ID		27287	81848
HPRD ID		06197	10466
Ensembl ID		ENSG00000151650	ENSG00000187678
Uniprot IDs		O95231	A0A0C4DFS6 Q9C004
PDB IDs			3BUN
Enriched GO Terms of Interacting Partners?
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