ARFIP1 and SMPD2

Data Source:
BioGRID (two hybrid)

		ARFIP1	SMPD2
Description		ADP ribosylation factor interacting protein 1	sphingomyelin phosphodiesterase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytosol Trans-Golgi Network Membrane	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Caveola Membrane Cell Periphery
	Molecular Function	Protein Binding Phospholipid Binding Protein Domain Specific Binding Phosphatidylinositol-4-phosphate Binding	Phospholipase Activity Sphingomyelin Phosphodiesterase Activity Protein Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Protein Secretion Negative Regulation Of Retrograde Transport, Endosome To Golgi	Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Glycosphingolipid Metabolic Process Response To Mechanical Stimulus Sphingolipid Catabolic Process Intracellular Signal Transduction Ceramide Biosynthetic Process Positive Regulation Of Ceramide Biosynthetic Process
Pathways			Glycosphingolipid metabolism Ceramide signalling TNFR1-mediated ceramide production
Drugs
Diseases
GWAS		Blood protein levels ( 29875488) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean platelet volume ( 32888494) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Height ( 18391951)
Interacting Genes		19 interacting genes: AFF1 ARF1 ARF3 ARF5 ARFIP2 BSND CMTM5 DESI2 KRT27 KRT33B MAGEA6 RPRM SCAMP1 SFT2D1 SLC2A4 SMIM5 SMPD2 SYNGR3 TNFRSF10D	15 interacting genes: ARFIP1 CCN1 COQ8A GAD2 NDRG4 PBX3 PGRMC2 PIK3CG PITPNC1 SLC10A1 SLC7A8 STAR TMEM14B TMEM167B TMEM31
Entrez ID		27236	6610
HPRD ID		09331	04608
Ensembl ID		ENSG00000164144	ENSG00000135587
Uniprot IDs		B4E273 B7ZA10 P53367 Q8N8M9	O60906
PDB IDs
Enriched GO Terms of Interacting Partners?
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