GLS2 and PDE2A

Data Source:
HPRD (in vivo)

		GLS2	PDE2A
Description		glutaminase 2	phosphodiesterase 2A
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Nucleus Cytoplasm Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Presynaptic Membrane Perinuclear Region Of Cytoplasm Synaptic Membrane
	Molecular Function	Glutaminase Activity Protein Binding	Magnesium Ion Binding 3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity CGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity Protein Binding Zinc Ion Binding CAMP Binding CGMP Binding TPR Domain Binding Phosphate Ion Binding Protein Homodimerization Activity 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Cellular Amino Acid Metabolic Process Glutamate Biosynthetic Process Glutamine Catabolic Process Cellular Amino Acid Biosynthetic Process Glutamate Secretion Regulation Of Apoptotic Process Reactive Oxygen Species Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Valve Development Ventricular Septum Development Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of CGMP-mediated Signaling Negative Regulation Of CGMP-mediated Signaling Regulation Of Mitochondrion Organization CAMP-mediated Signaling CGMP-mediated Signaling Aorta Development Cellular Response To Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Vascular Permeability Positive Regulation Of Vascular Permeability Regulation Of CAMP-mediated Signaling Negative Regulation Of CAMP-mediated Signaling CGMP Catabolic Process Positive Regulation Of Inflammatory Response Establishment Of Endothelial Barrier Cellular Response To Mechanical Stimulus Cellular Response To CAMP Cellular Response To CGMP Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To 2,3,7,8-tetrachlorodibenzodioxine
Pathways		Glutamate Neurotransmitter Release Cycle TP53 Regulates Metabolic Genes Glutamate and glutamine metabolism	cGMP effects G alpha (s) signalling events
Drugs		Glutamic acid	Caffeine Cyclic GMP ND7001 ND7001 Exisulind 3-isobutyl-1-methyl-7H-xanthine Tofisopam Doxofylline Trapidil
Diseases
GWAS		Adverse response to drug ( 30420678) Amino acid levels ( 26068415) Axial length ( 24144296) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glycine levels ( 30837465) Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Serum metabolite levels ( 31636271 23093944) Serum metabolite levels (CMS) ( 31636271)	Household income (MTAG) ( 31844048) Optic nerve measurement (cup area) ( 20395239) Rheumatoid arthritis ( 22446963)
Interacting Genes		14 interacting genes: CASK DLG1 DLG2 DLG3 DLG4 GRHPR HIP1 PAG1 PATJ RALA RGS3 SNTA1 TAX1BP3 XAF1
Entrez ID		27165	5138
HPRD ID		05901	04041
Ensembl ID		ENSG00000135423	ENSG00000186642
Uniprot IDs		A0A087X004 Q9UI32	O00408 Q8IW54
PDB IDs		4BQM 5U0K	1Z1L 3IBJ 3ITM 3ITU 4C1I 4D08 4D09 4HTX 4HTZ 4JIB 5TZ3 5TZA 5TZC 5TZH 5TZW 5TZX 5TZZ 5U00 5U7D 5U7I 5U7J 5U7K 5U7L 5VP0 5VP1 5XKM 6B96 6B97 6B98 6BLF 6C7D 6C7E 6C7F 6C7G 6C7I 6C7J 6CYB 6CYC 6CYD 6ZND 6ZQZ
Enriched GO Terms of Interacting Partners?
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