OPLAH and ZNF451

Data Source:
BioGRID (two hybrid)

		OPLAH	ZNF451
Description		5-oxoprolinase, ATP-hydrolysing	zinc finger protein 451
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleus PML Body
	Molecular Function	Protein Binding ATP Binding 5-oxoprolinase (ATP-hydrolyzing) Activity Identical Protein Binding	Transcription Corepressor Activity Protein Binding Metal Ion Binding SUMO Ligase Activity
	Biological Process	Glutathione Metabolic Process Glutathione Biosynthetic Process	Regulation Of Gene Expression Protein Sumoylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Histone H3-K9 Acetylation
Pathways		Glutathione synthesis and recycling Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)
Drugs		Glutamic acid
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Blood metabolite levels ( 24816252) Mean spheric corpuscular volume ( 32888494) Metabolic traits ( 21886157) Serum metabolite levels ( 23093944)
Interacting Genes		4 interacting genes: GK POU6F2 TPK1 ZNF451	33 interacting genes: AR CALCOCO2 CDC5L CDCA4 CPTP CREB1 CREBBP FAM118A FXR2 HTT JMJD6 KDM1A KLHL40 LZTR1 MID2 OPLAH PCBD1 PIAS1 PIAS2 PIK3R3 PML PRMT1 PRMT8 PRPF40A RAP1GDS1 RNF40 SNIP1 SUMO1 SUMO2 SUV39H1 UBC UBE2I ZNF467
Entrez ID		26873	26036
HPRD ID		14880	10332
Ensembl ID		ENSG00000178814	ENSG00000112200
Uniprot IDs		O14841	B4DYS2 Q96JY2 Q9Y4E5
PDB IDs			5D2M
Enriched GO Terms of Interacting Partners?
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