GGCX and ST3GAL4

Data Source:
HPRD (in vivo, in vitro)

		GGCX	ST3GAL4
Description		gamma-glutamyl carboxylase	ST3 beta-galactoside alpha-2,3-sialyltransferase 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Golgi Membrane Extracellular Region Membrane Integral Component Of Membrane Golgi Cisterna Membrane
	Molecular Function	Gamma-glutamyl Carboxylase Activity Vitamin Binding	Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity Neolactotetraosylceramide Alpha-2,3-sialyltransferase Activity N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Sialyltransferase Activity Monosialoganglioside Sialyltransferase Activity
	Biological Process	Cellular Protein Modification Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation	Protein Glycosylation Glycoprotein Biosynthetic Process Glycolipid Biosynthetic Process Oligosaccharide Biosynthetic Process O-glycan Processing Keratan Sulfate Biosynthetic Process Positive Regulation Of Blood Coagulation Lipid Glycosylation Cognition Sialylation Positive Regulation Of Leukocyte Tethering Or Rolling Protein Sialylation
Pathways		Gamma-carboxylation of protein precursors Gamma-carboxylation of protein precursors Defective gamma-carboxylation of F9	Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Sialic acid metabolism Lewis blood group biosynthesis Maturation of protein 3a Maturation of spike protein Maturation of protein 3a N-Glycan antennae elongation Termination of O-glycan biosynthesis
Drugs		Coagulation factor VIIa Recombinant Human Coagulation Factor IX (Recombinant) Glutamic acid Menadione Phylloquinone Anisindione Kappadione Coagulation Factor IX Human
Diseases		Pseudoxanthoma elasticum, including: Pseudoxanthoma elasticum (PXE); Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS		Coronary artery disease ( 29212778 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) High light scatter reticulocyte count ( 32888494) Myocardial infarction ( 26343387) Prostate cancer ( 21743467) Triglyceride levels ( 32203549)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Blood protein levels ( 29875488) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 25961943 20686565) Coronary artery disease ( 29212778) Factor VIII levels ( 30586737) HDL cholesterol levels ( 32203549) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 31562340) High light scatter reticulocyte count ( 32888494) LDL cholesterol ( 24097068 30275531 25961943 20686565) LDL cholesterol levels ( 32203549 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alkaline phosphatase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494 27863252) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 23823483) Mumps ( 28928442) N-glycan levels ( 31163085) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 31666285 29403010) Soluble E-selectin levels ( 31217265) Total cholesterol levels ( 28334899 30275531) vWF levels ( 30586737)
Interacting Genes		7 interacting genes: BGLAP F10 F2 F7 F9 PROC SRPK2	2 interacting genes: ARHGDIA CD8B
Entrez ID		2677	6484
HPRD ID		00665	00084
Ensembl ID		ENSG00000115486	ENSG00000110080
Uniprot IDs		P38435	Q11206 Q6IBE6
PDB IDs
Enriched GO Terms of Interacting Partners?
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