GGCX and FXN

Data Source:
BioGRID (affinity chromatography technology)

		GGCX	FXN
Description		gamma-glutamyl carboxylase	frataxin
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Mitochondrion Mitochondrial Matrix Cytosol L-cysteine Desulfurase Complex
	Molecular Function	Gamma-glutamyl Carboxylase Activity Vitamin Binding	Ferroxidase Activity Protein Binding Ferrous Iron Binding Ferric Iron Binding Iron Chaperone Activity 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Cellular Protein Modification Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation	Oxidative Phosphorylation Heme Biosynthetic Process Ion Transport Cellular Iron Ion Homeostasis Mitochondrion Organization Adult Walking Behavior Positive Regulation Of Cell Population Proliferation Aerobic Respiration Embryo Development Ending In Birth Or Egg Hatching Response To Iron Ion Regulation Of Ferrochelatase Activity Iron-sulfur Cluster Assembly Protein Autoprocessing Iron Incorporation Into Metallo-sulfur Cluster Proprioception Positive Regulation Of Cell Growth Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Small Molecule Metabolic Process Negative Regulation Of Organ Growth Positive Regulation Of Lyase Activity Cellular Response To Hydrogen Peroxide Negative Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Succinate Dehydrogenase Activity Positive Regulation Of Aconitate Hydratase Activity
Pathways		Gamma-carboxylation of protein precursors Gamma-carboxylation of protein precursors Defective gamma-carboxylation of F9	Mitochondrial protein import Mitochondrial protein import Mitochondrial iron-sulfur cluster biogenesis
Drugs		Coagulation factor VIIa Recombinant Human Coagulation Factor IX (Recombinant) Glutamic acid Menadione Phylloquinone Anisindione Kappadione Coagulation Factor IX Human	Iron Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases		Pseudoxanthoma elasticum, including: Pseudoxanthoma elasticum (PXE); Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency Combined deficiency of vitamin K-dependent clotting factors (VKCFD)	Friedreich ataxia
GWAS		Coronary artery disease ( 29212778 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) High light scatter reticulocyte count ( 32888494) Myocardial infarction ( 26343387) Prostate cancer ( 21743467) Triglyceride levels ( 32203549)	Headache ( 29397368) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Refractive error ( 32231278) Seasonality ( 25562672)
Interacting Genes		7 interacting genes: BGLAP F10 F2 F7 F9 PROC SRPK2	6 interacting genes: ACTN1 DAPP1 GOLGA6L9 PICK1 PMPCB RNF126
Entrez ID		2677	2395
HPRD ID		00665	06013
Ensembl ID		ENSG00000115486	ENSG00000165060
Uniprot IDs		P38435	A0A0S2Z3G4 Q16595
PDB IDs			1EKG 1LY7 3S4M 3S5D 3S5E 3S5F 3T3J 3T3K 3T3L 3T3T 3T3X 5KZ5 6NZU
Enriched GO Terms of Interacting Partners?
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