FXN and PMPCB

Data Source:
HPRD (two hybrid, in vitro)

		FXN	PMPCB
Description		frataxin	peptidase, mitochondrial processing subunit beta
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol L-cysteine Desulfurase Complex	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Processing Peptidase Complex
	Molecular Function	Ferroxidase Activity Protein Binding Ferrous Iron Binding Ferric Iron Binding Iron Chaperone Activity 2 Iron, 2 Sulfur Cluster Binding	Metalloendopeptidase Activity Metal Ion Binding
	Biological Process	Oxidative Phosphorylation Heme Biosynthetic Process Ion Transport Cellular Iron Ion Homeostasis Mitochondrion Organization Adult Walking Behavior Positive Regulation Of Cell Population Proliferation Aerobic Respiration Embryo Development Ending In Birth Or Egg Hatching Response To Iron Ion Regulation Of Ferrochelatase Activity Iron-sulfur Cluster Assembly Protein Autoprocessing Iron Incorporation Into Metallo-sulfur Cluster Proprioception Positive Regulation Of Cell Growth Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Small Molecule Metabolic Process Negative Regulation Of Organ Growth Positive Regulation Of Lyase Activity Cellular Response To Hydrogen Peroxide Negative Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Succinate Dehydrogenase Activity Positive Regulation Of Aconitate Hydratase Activity	Protein Processing Involved In Protein Targeting To Mitochondrion Mitochondrial Calcium Ion Transmembrane Transport
Pathways		Mitochondrial protein import Mitochondrial protein import Mitochondrial iron-sulfur cluster biogenesis	Mitochondrial protein import Processing of SMDT1
Drugs		Iron Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases		Friedreich ataxia
GWAS		Headache ( 29397368) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Refractive error ( 32231278) Seasonality ( 25562672)	Diverticular disease ( 30177863)
Interacting Genes		6 interacting genes: ACTN1 DAPP1 GOLGA6L9 PICK1 PMPCB RNF126	5 interacting genes: FXN MARK3 NPSR1 PMPCA PTGER4
Entrez ID		2395	9512
HPRD ID		06013	07539
Ensembl ID		ENSG00000165060	ENSG00000105819
Uniprot IDs		A0A0S2Z3G4 Q16595	B3KM34 O75439 Q96CP5
PDB IDs		1EKG 1LY7 3S4M 3S5D 3S5E 3S5F 3T3J 3T3K 3T3L 3T3T 3T3X 5KZ5 6NZU
Enriched GO Terms of Interacting Partners?
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