GDI2 and GLRA2

Data Source:
BioGRID (two hybrid)

		GDI2	GLRA2
Description		GDP dissociation inhibitor 2	glycine receptor alpha 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Focal Adhesion Membrane Vesicle Secretory Granule Lumen Azurophil Granule Lumen Synapse Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Chloride Channel Complex Neuron Projection Synapse Postsynaptic Membrane Glycinergic Synapse
	Molecular Function	RNA Binding Rab GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding	Transmembrane Signaling Receptor Activity Chloride Channel Activity Glycine Binding Extracellularly Glycine-gated Chloride Channel Activity Glycine-gated Chloride Ion Channel Activity Neurotransmitter Receptor Activity Metal Ion Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Signal Transduction Small GTPase Mediated Signal Transduction Protein Transport Vesicle-mediated Transport Neutrophil Degranulation Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Signal Transduction Neuropeptide Signaling Pathway Chemical Synaptic Transmission Ion Transmembrane Transport Regulation Of Membrane Potential Response To Amino Acid Nervous System Process Synaptic Transmission, Glycinergic Excitatory Postsynaptic Potential Cellular Response To Amino Acid Stimulus Cellular Response To Zinc Ion Cellular Response To Ethanol Chloride Transmembrane Transport
Pathways		Neutrophil degranulation RAB GEFs exchange GTP for GDP on RABs	Neurotransmitter receptors and postsynaptic signal transmission Neurotransmitter receptors and postsynaptic signal transmission
Drugs			Glycine Lindane Picrotoxin Ethanol Memantine Taurine
Diseases
GWAS		Blood protein levels ( 30072576) Cutaneous malignant melanoma ( 32341527) Osteosarcoma ( 23727862)
Interacting Genes		9 interacting genes: GLRA2 HSPB1 LINC01554 RAB11A RAB2A RAB4A RAB5A RAB8A RAB9A	5 interacting genes: BAG6 DDX24 GDI2 PSD SEC23A
Entrez ID		2665	2742
HPRD ID		02863	02379
Ensembl ID		ENSG00000057608	ENSG00000101958
Uniprot IDs		P50395 Q6IAT1	P23416
PDB IDs
Enriched GO Terms of Interacting Partners?
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