GREM1 and KRTAP12-2

Data Source:
BioGRID (two hybrid)

		GREM1	KRTAP12-2
Description		gremlin 1, DAN family BMP antagonist	keratin associated protein 12-2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cell Surface Collagen-containing Extracellular Matrix	Cytosol Keratin Filament
	Molecular Function	Cytokine Activity Protein Binding Morphogen Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity BMP Binding Protein Homodimerization Activity Vascular Endothelial Growth Factor Receptor 2 Binding Receptor Ligand Activity	Protein Binding
	Biological Process	Cell Morphogenesis Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Receptor Internalization Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Apoptotic Process Signal Transduction Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Proximal/distal Pattern Formation Regulation Of Epithelial To Mesenchymal Transition Collagen Fibril Organization Negative Regulation Of Cell Growth Embryonic Limb Morphogenesis Negative Regulation Of Bone Mineralization Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Chondrocyte Differentiation Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Proliferation Sequestering Of BMP From Receptor Via BMP Binding Negative Regulation Of Apoptotic Process Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Bone Remodeling Determination Of Dorsal Identity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Focal Adhesion Assembly Positive Regulation Of Telomerase Activity Limb Development Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Ureteric Bud Formation Positive Regulation Of Protein Tyrosine Kinase Activity Signal Transduction By P53 Class Mediator Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Osteoclast Proliferation Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Bone Trabecula Formation Negative Regulation Of Bone Mineralization Involved In Bone Maturation Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Signaling Receptor Activity Positive Regulation Of Cardiac Muscle Cell Differentiation	Keratinization
Pathways			Keratinization
Drugs
Diseases
GWAS		Chin dimples ( 27182965) Colorectal cancer ( 25990418 21761138 26151821 24737748 23266556) Colorectal cancer or advanced adenoma ( 30510241) Hypospadias ( 25108383) Metabolite levels ( 23823483) Monobrow ( 27182965) Orofacial clefts ( 20023658)
Interacting Genes		4 interacting genes: BMP2 KRTAP12-2 MDFI YWHAH	125 interacting genes: ADAM12 ARID5A ATN1 ATP6V1C2 AVPI1 BCL6B BEX2 CATSPER1 CBLL2 CBX2 CCNL1 CCNL2 CFP CHRD CNNM3 CYSRT1 DGCR6 DHRS1 EFEMP2 ETNK2 FAM27E3 FHL3 FOXD4 FOXD4L1 FOXD4L3 GDF15 GPANK1 GPRIN2 GREM1 HOXA1 HOXB9 HSFX1 HSFX2 HYPK INO80B IQUB KRT34 KRTAP10-5 KRTAP10-8 KRTAP12-1 KRTAP12-4 KRTAP13-2 KRTAP15-1 KRTAP19-2 KRTAP21-2 KRTAP26-1 KRTAP3-2 KRTAP4-2 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-3 KRTAP9-8 LCE1A LCE1C LCE1F LCE2A LCE2B LCE4A LINC00671 MEOX2 MGAT5B MYOZ1 MYPOP NBPF19 NECTIN2 NOTCH2NLA NPDC1 NR1D2 ODF1 OTX1 PACSIN3 PATZ1 PCSK5 PDE9A PELO PHLDA1 PIH1D2 PLAC8 POLR1C POM121L8P POU4F2 RAD23A RBM39 RBPMS RBX1 RHOXF2 SEMA3B SLC12A4 SLC13A5 SLC15A2 SLC15A3 SPATA3 SPRED2 SPRY1 SRSF8 TCEA2 TEX37 TINAGL1 TLE5 TMEM179B TNS2 TRIM42 TRIP13 TSGA10IP TTPA VASN VENTX VGLL3 YIPF3 YY1 ZBTB9 ZDHHC1 ZIM2 ZNF100 ZNF408 ZNF497 ZNF581 ZNF587 ZNF624 ZNF688 ZNF696 ZNF764 ZNF785 ZNHIT1
Entrez ID		26585	353323
HPRD ID		07048	11198
Ensembl ID		ENSG00000166923	ENSG00000221864
Uniprot IDs		A6XAA7 B3KTR9 O60565	P59991
PDB IDs		5AEJ
Enriched GO Terms of Interacting Partners?
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