GCKR and EP300

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)

		GCKR	EP300
Description		glucokinase regulator	E1A binding protein p300
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol	Histone Acetyltransferase Complex Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Cytosol Protein-DNA Complex
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Enzyme Binding Carbohydrate Binding Fructose-6-phosphate Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding P53 Binding DNA Binding Chromatin Binding Damaged DNA Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Protein Binding Beta-catenin Binding Protein C-terminus Binding Transcription Factor Binding Zinc Ion Binding Acetyltransferase Activity Transferase Activity, Transferring Acyl Groups Chromatin DNA Binding Activating Transcription Factor Binding Nuclear Hormone Receptor Binding Tau Protein Binding Androgen Receptor Binding NF-kappaB Binding Peptide-lysine-N-acetyltransferase Activity Protein Propionyltransferase Activity Pre-mRNA Intronic Binding STAT Family Protein Binding Peptide Butyryltransferase Activity Histone Crotonyltransferase Activity Histone Butyryltransferase Activity
	Biological Process	Carbohydrate Metabolic Process Regulation Of Glycolytic Process Protein Import Into Nucleus Response To Fructose Negative Regulation Of Glucokinase Activity Glucose Homeostasis Urate Metabolic Process Triglyceride Homeostasis Carbohydrate Derivative Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Somitogenesis Thigmotaxis Behavioral Defense Response Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Glycolytic Process Transcription-coupled Nucleotide-excision Repair Regulation Of Transcription, DNA-templated Protein Acetylation Internal Protein Amino Acid Acetylation Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Nervous System Development Heart Development Skeletal Muscle Tissue Development Learning Or Memory Circadian Rhythm Animal Organ Morphogenesis Regulation Of Autophagy Macrophage Derived Foam Cell Differentiation Regulation Of Mitochondrion Organization Positive Regulation Of Neuron Projection Development Viral Process Histone Acetylation Protein Deubiquitination N-terminal Peptidyl-lysine Acetylation Protein Phosphopantetheinylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation B Cell Differentiation Platelet Formation Lung Development Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Protein Destabilization Positive Regulation Of Protein Binding Positive Regulation Of Type I Interferon Production Cellular Response To UV Multicellular Organism Growth Megakaryocyte Development Swimming Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To Estrogen Positive Regulation By Host Of Viral Transcription Histone H4 Acetylation Histone H2B Acetylation Fat Cell Differentiation Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gluconeogenesis Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Face Morphogenesis Regulation Of Androgen Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Peptidyl-lysine Propionylation Regulation Of Tubulin Deacetylation Peptidyl-lysine Crotonylation Peptidyl-lysine Butyrylation Regulation Of Cellular Response To Heat Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Signal Transduction By P53 Class Mediator Beta-catenin-TCF Complex Assembly Positive Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Pathways		Regulation of Glucokinase by Glucokinase Regulatory Protein Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	Regulation of gene expression by Hypoxia-inducible Factor RORA activates gene expression Polo-like kinase mediated events Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation PPARA activates gene expression PPARA activates gene expression Formation of the beta-catenin:TCF transactivating complex Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production HATs acetylate histones Attenuation phase Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Circadian Clock B-WICH complex positively regulates rRNA expression Activation of anterior HOX genes in hindbrain development during early embryogenesis CD209 (DC-SIGN) signaling Metalloprotease DUBs Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Methylation PI5P Regulates TP53 Acetylation Activation of the TFAP2 (AP-2) family of transcription factors RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling Regulation of RUNX3 expression and activity RUNX3 regulates p14-ARF NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NGF-stimulated transcription NGF-stimulated transcription TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation FOXO-mediated transcription of cell death genes Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis Regulation of FOXO transcriptional activity by acetylation Regulation of FOXO transcriptional activity by acetylation
Drugs
Diseases			Rubinstein-Taybi syndrome
GWAS		Albumin-globulin ratio ( 29403010) Alcohol consumption ( 27911795 28937693 31358974) Alcohol consumption (drinkers vs non-drinkers) ( 31959922) Alcohol consumption (drinks per week) ( 28485404 30643258 30679032) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol consumption in current drinkers ( 28937693) Alcohol use disorder ( 30940813) Alcohol use disorder (consumption score) ( 30940813 30336701) Alcohol use disorder (total score) ( 30336701) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 29403010) Bitter alcoholic beverage consumption ( 31046077) Bitter beverage consumption ( 31046077) Blood glucose levels ( 29615537) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Blood protein levels in cardiovascular risk ( 28369058) Blood sugar levels ( 29403010) Branched-chain amino acid levels (Isoleucine) ( 27898682) Branched-chain amino acid levels (Leucine) ( 27898682) Branched-chain amino acid levels (Valine) ( 27898682) Breast size ( 22747683) C-reactive protein ( 18439548) C-reactive protein levels ( 29403010 30388399 21300955) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Calcium levels ( 24068962 20705733) Cardiovascular disease risk factors ( 21943158) Chloride levels ( 29403010) Cholesterol ( 31902109) Cholesterol, total ( 24097068 25961943 20686565 26582766) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic kidney disease ( 29124443 20383146) circulating leptin levels ( 32917775 26833098) circulating leptin levels adjusted for BMI ( 32917775 26833098) Circulating leptin levels or fasting insulin levels ( 32341051) Circulating leptin levels or HOMA-IR ( 32341051) Circulating leptin levels or type 2 diabetes ( 32341051) Coffee consumption ( 31959922 31046077) Coffee consumption (cups per day) ( 31837886 25288136) Creatine kinase levels ( 29403010) Creatinine levels ( 29403010) Crohn's disease ( 28067908 21102463) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Factor VII activity ( 30642921) Factor VII activity or levels ( 30642921) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood glucose adjusted for BMI ( 25625282) Fasting blood insulin ( 25631608 20081858 22581228) Fasting blood insulin (BMI interaction) ( 22581228) Fasting blood insulin adjusted for BMI ( 25625282) Fasting plasma glucose ( 25187374 28270201 22508271) Fasting triglyceride levels ( 32603185) Gallstone disease ( 30504769 27094239) Gamma glutamyl transferase levels ( 29403010) Gestational insulin sensitivity ( 32556615) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Glucose homeostasis traits ( 25524916) Glycemic traits (pleiotropy) ( 31021400) Glycemic traits (pregnancy) ( 23903356) Gondoic acid (20:1n-9) levels ( 28298293) Gout ( 25646370 32238385 31578528 27899376) Gout (combined type) ( 32238385) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 25282103 31562340) Hematocrit ( 32888494 27863252) Hematological and biochemical traits ( 20139978) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Homeostasis model assessment of insulin resistance ( 20081858) Hypertriglyceridemia ( 31910446 27599772 23505323 20657596) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 28067908) Kidney stones ( 31729369) L-selectin levels ( 25576479) Lactate dehydrogenase levels ( 29403010) LDL cholesterol ( 18179892 30275531) LDL cholesterol levels ( 32203549) Lipid metabolism phenotypes ( 19936222) Lipid traits ( 24386095 24023260) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Liver fat content (MRI proton density fat fraction measure) ( 32247823) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte counts ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 22399527 30382898 31589552) Metabolic syndrome (multivariate analysis) ( 29632305) Metabolic traits ( 19060910 21886157) Metabolite levels ( 21909109 22286219 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 22558069) Non-oily fish consumption ( 32066663) Nonalcoholic fatty liver disease ( 29385134) Nonalcoholic steatohepatitis ( 32298765) Palmitic acid (16:0) levels ( 23362303) Palmitoleic acid (16:1n-7) levels ( 28298293 23362303) Percent glycated albumin ( 29844224) Phospholipid levels (plasma) ( 22359512) Plasma lactate levels ( 26433129) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Platelet count ( 22139419 29403010 32888494 27863252) Plateletcrit ( 32888494 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Postprandial triglyceride levels ( 32603185) Problematic alcohol use ( 32451486) Protein C levels ( 28082259) Prothrombin time ( 29403010) Red blood cell count ( 27863252) Red cell distribution width ( 32888494 27863252) Refractive error ( 32231278) Relative protein intake ( 32393786) Renal overload gout ( 27899376) Renal underexcretion gout ( 32238385 27899376) Resting heart rate ( 29769521 27798624) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum albumin level ( 23022100 29403010) Serum alkaline phosphatase levels ( 31666285) Serum alpha1-antitrypsin levels ( 26174136) Serum metabolite levels ( 31636271 23093944) Serum metabolite levels (CMS) ( 31636271) Serum total protein level ( 23022100 29403010) Serum uric acid levels ( 30993211 29403010) Sex hormone-binding globulin levels ( 22829776) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Total body bone mineral density ( 29304378) Total cholesterol levels ( 28334899 31087446 29403010 29615537 30275531) Total triglycerides levels ( 26690388) Triglyceride levels ( 30718733 28334899 31087446 31647587 32154731 30911093 29403010 29615537) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 23726366 24097068 29404214 21909109 18193043 18193044 20864672 26160806 19060906 19060911 20139978 30275531 17463246 25961943 26780889 20686565 26582766) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Two-hour glucose challenge ( 20081857) Type 2 diabetes ( 28566273 22885922 30054458 30297969 29632382 26818947 32499647 30718926 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382) Urate levels ( 31985003 20884846 31578528 20139978 23263486) Urate levels in obese individuals ( 25811787) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 19503597) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) Urinary sodium excretion ( 31409800) Urinary sodium to creatinine ratio ( 30910378) Urolithiasis ( 30975718) Waist Circumference - Triglycerides (WC-TG) ( 21386085) Waist circumference and related phenotypes ( 18454146) White blood cell count ( 29403010 32888494 27863252 24777453)	Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 22936669) General risk tolerance (MTAG) ( 30643258) Neuroticism ( 29255261) Red cell distribution width ( 32888494) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656) Type 2 diabetes ( 30297969)
Interacting Genes		4 interacting genes: CDKN1A EP300 GCK TRAF2	374 interacting genes: ABL1 ACSM5 ACTA2 ACTB AHR AKT1 ALKBH4 ALX1 APEX1 AR ARHGDIA ARNT ARNTL ARSF ASCL1 ASH2L ATF4 ATF5 ATR AUTS2 BAG6 BCAS2 BCL3 BCL6 BRCA1 BRMS1 C1R CALCOCO1 CARM1 CCNB1 CCND1 CDK1 CDK2 CDT1 CDX2 CEBPA CEBPB CEBPD CFH CHD4 CITED1 CITED2 CITED4 CLOCK CNOT4 COPS2 COPS6 CREBBP CRX CTBP1 CTBP2 CTF1 CTNNB1 CXCL8 CXXC1 DAO DBP DDIT3 DDX24 DDX5 DECR2 DEK DTX1 DUX4 E2F1 E2F5 EEF1A1 EEF2 EGR1 EID1 EID2 ELF3 ELK1 ELL EMB EPAS1 EPO ESR1 ESR2 ETS1 ETS2 ETV1 ETV4 FBXL5 FEN1 FHL2 FOSB FOSL1 FOSL2 FOXO3 FOXP3 GAA GABPA GATA2 GATA4 GATA5 GATA6 GCKR GLUL GOLGA2 GPBP1 GPS2 GRB2 GRIP1 GTF2B H1-1 H1-3 H2AC20 H2AC21 H2AC4 H2BC21 H2BC3 H3-3A H3-4 H3C1 H3C14 H4-16 H4C1 H4C14 H4C9 HAND2 HBP1 HDAC1 HDAC3 HDAC6 HEMGN HERC1 HIF1A HMGB1 HMGN1 HMGN2 HNF1A HNRNPU HNRNPUL1 HOXA10 HOXB1 HOXB2 HOXB3 HOXB4 HOXB6 HOXB7 HOXB9 HOXD10 HOXD4 HPS6 HSP90AA2P ILF2 ILF3 IMMT ING1 ING2 ING4 ING5 IRF1 IRF2 IRF3 IRF5 IRF7 ITIH3 JDP2 JMY JUN JUNB JUND KAT2A KAT2B KAT5 KCTD5 KDM2A KLF1 KLF13 KLF2 KLF4 KLF5 KPNA2 KRT18 LEF1 MAF MAGED1 MAML1 MAP2K1 MAP3K5 MAPK1 MAPK8 MAPT MAX MCL1 MCM2 MCM3 MCM3AP MCM4 MCM5 MDC1 MDM2 MDM4 MEF2A MEF2C MEF2D MGMT MITF MN1 MORF4L1 MPG MRE11 MSH6 MSTO1 MTOR MYB MYBL2 MYC MYOD1 N4BP2 NAP1L1 NAP1L4 NBN NCOA1 NCOA2 NCOA3 NCOA6 NEDD1 NEIL2 NEUROD1 NFATC1 NFATC2 NFYB NOTCH1 NOXA1 NPAS2 NPM1 NR1H4 NR1I2 NR2F2 NR4A1 NUP98 NUPR1 OLIG2 ORC2 PAK2 PAX5 PAX6 PAX8 PAXIP1 PCK2 PCNA PDHX PELP1 PIAS1 PIAS3 PIN1 PLAGL1 PLG PLSCR1 PLSCR2 PML POLB POLD2 POLI POU3F2 PPARA PPARD PPARG PPP2R5C PRKCA PRKCB PRKCD PRKDC PRMT1 PROX1 PTMA RACK1 RAD23A RAD50 RAN RB1 RBM14 RECQL4 REL RELA RORA RPL27 RPS6KA5 RPS6KB1 RPS6KB2 RUNX1 RUNX2 RUNX3 RUVBL2 SATB1 SAV1 SELENOP SENP3 SERTAD1 SET SETD1A SIRT1 SIRT2 SKP2 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD7 SNAI1 SNIP1 SNW1 SOX9 SP1 SP3 SPHK1 SPIB SREBF1 SREBF2 SRY SS18 SS18L1 STAT1 STAT2 STAT3 STAT5A STAT5B STAT6 SUB1 SUMO2 SUV39H1 TACC2 TADA3 TAF1B TAL1 TCF12 TCF3 TCF4 TCF7L2 TDG TERF2 TFAP2A TGFB1I1 TGS1 THPO TINAGL1 TNIP2 TP53 TP53BP1 TP63 TP73 TRAF2 TRERF1 TRIP4 TSG101 TWIST1 UBC UBE2D1 UBE2I UBQLN1 UBTF USF2 VPS18 WDR59 WDR82 XRCC6 YWHAZ YY1 ZBTB16 ZBTB17 ZBTB48 ZBTB49 ZBTB7B ZBTB8A ZC3H12A ZEB1 ZFPM2 ZNF148 ZNF76 ZRANB2
Entrez ID		2646	2033
HPRD ID		02909	04078
Ensembl ID		ENSG00000084734	ENSG00000100393
Uniprot IDs		A0A0C4DFN2 Q14397	Q09472 Q7Z6C1
PDB IDs		4BB9 4BBA 4LY9 4MQU 4MRO 4MSU 4OHK 4OHM 4OHO 4OHP 4OLH 4OP1 4OP2 4OP3 4PX2 4PX3 4PX5 4PXS	1L3E 1P4Q 2K8F 2MH0 2MZD 3BIY 3I3J 3IO2 3P57 3T92 4BHW 4PZR 4PZS 4PZT 5BT3 5KJ2 5LKT 5LKU 5LKX 5LKZ 5LPK 5LPM 5NU5 5XZC 6DS6 6FGN 6FGS 6GYR 6GYT 6K4N 6PF1 6PGU 6V8B 6V8K 6V8N 6V90
Enriched GO Terms of Interacting Partners?
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