GCHFR and PLCB2

Data Source:
HPRD (in vitro)

		GCHFR	PLCB2
Description		GTP cyclohydrolase I feedback regulator	phospholipase C beta 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Dendrite Nuclear Membrane Protein-containing Complex Melanosome	Cytosol
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Amino Acid Binding GTP-dependent Protein Binding GTP Cyclohydrolase Binding Protein-containing Complex Binding	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding
	Biological Process	Nitric Oxide Biosynthetic Process Negative Regulation Of Biosynthetic Process Neurotransmitter Metabolic Process Negative Regulation Of GTP Cyclohydrolase I Activity Protein-containing Complex Assembly	Phospholipid Metabolic Process G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Wnt Signaling Pathway, Calcium Modulating Pathway Lipid Catabolic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Sensory Perception Of Bitter Taste
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors
Drugs
Diseases
GWAS		Anxiety and stress-related disorders ( 31116379) Malaria ( 31844061) Triglycerides ( 30275531)	Chronic kidney disease ( 30226566) Coronary artery disease ( 30402224) Hypertension ( 30226566) Ischemic stroke ( 29930801) Myocardial infarction ( 30226566) Neutrophil count ( 32888494) Schizophrenia ( 25056061 29483656) White blood cell count ( 32888494)
Interacting Genes		1 interacting genes: GCH1	7 interacting genes: GNAQ MAP2K3 MAP2K6 SLC9A3R1 SNCA TRPC3 TRPM7
Entrez ID		2644	5330
HPRD ID		03895	04985
Ensembl ID		ENSG00000137880	ENSG00000137841
Uniprot IDs		P30047	Q00722 Q59F77 Q9BVT6
PDB IDs			2FJU 2ZKM
Enriched GO Terms of Interacting Partners?
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