GCHFR and GCH1

Data Source:
HPRD (in vitro)

		GCHFR	GCH1
Description		GTP cyclohydrolase I feedback regulator	GTP cyclohydrolase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Dendrite Nuclear Membrane Protein-containing Complex Melanosome	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Neuron Projection Terminus
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Amino Acid Binding GTP-dependent Protein Binding GTP Cyclohydrolase Binding Protein-containing Complex Binding	GTPase Activity GTP Cyclohydrolase I Activity Calcium Ion Binding Protein Binding GTP Binding Zinc Ion Binding GTP-dependent Protein Binding Translation Initiation Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Nitric Oxide Biosynthetic Process Negative Regulation Of Biosynthetic Process Neurotransmitter Metabolic Process Negative Regulation Of GTP Cyclohydrolase I Activity Protein-containing Complex Assembly	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Heart Rate Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Interferon-gamma Response To Tumor Necrosis Factor 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Vasodilation Dopamine Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Negative Regulation Of Blood Pressure Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Positive Regulation Of Nitric-oxide Synthase Activity Protein-containing Complex Assembly Regulation Of Removal Of Superoxide Radicals
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs			Guanine
Diseases			Primary torsion dystonia (PTD) Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Anxiety and stress-related disorders ( 31116379) Malaria ( 31844061) Triglycerides ( 30275531)	Chronotype ( 30696823) Mercury levels ( 26025379) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Parkinson's disease ( 25064009 32201043 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 22446963)
Interacting Genes		1 interacting genes: GCH1	15 interacting genes: AHSA1 ATP1B1 CDC37 CNRIP1 GCHFR GIT2 HSPA8 RAB26 RLF RPH3A SH3GL2 SP3 TNPO2 TNPO3 YWHAZ
Entrez ID		2644	2643
HPRD ID		03895	02573
Ensembl ID		ENSG00000137880	ENSG00000131979
Uniprot IDs		P30047	A0A024R642 P30793 Q8IZH9
PDB IDs			1FB1
Enriched GO Terms of Interacting Partners?
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