GATM and ACSL6

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		GATM	ACSL6
Description		glycine amidinotransferase	acyl-CoA synthetase long chain family member 6
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Extracellular Exosome	Mitochondrial Outer Membrane Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Amidinotransferase Activity Glycine Amidinotransferase Activity	Long-chain Fatty Acid-CoA Ligase Activity ATP Binding Protein Homodimerization Activity Arachidonate-CoA Ligase Activity
	Biological Process	Creatine Metabolic Process Creatine Biosynthetic Process Multicellular Organism Development Learning Or Memory Muscle Atrophy Positive Regulation Of Cold-induced Thermogenesis	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Lipid Biosynthetic Process Long-chain Fatty-acyl-CoA Biosynthetic Process
Pathways		Creatine metabolism	Synthesis of very long-chain fatty acyl-CoAs
Drugs		Ornithine Glycine Delta-Amino Valeric Acid gamma-Aminobutyric acid Norvaline Alpha-Aminobutyric Acid
Diseases		Creatine deficiency syndrome, including: Arginine:glycine amidinotransferase deficiency (AGAT deficiency); Guanidinoacetate methyltransferase deficiency (GAMT deficiency); X-linked creatine deficiency syndrome (XL-CDS)
GWAS		Chronic kidney disease ( 31152163 26831199 20383146) Creatinine levels ( 31015462) Estimated glomerular filtration rate ( 31152163 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Homoarginine levels ( 24047826) Metabolite levels (small molecules and protein measures) ( 27005778) Phosphatidylcholine-ether levels ( 31551469) Renal function and chronic kidney disease ( 19430482) Serum metabolite levels ( 24625756) Urinary albumin-to-creatinine ratio ( 31511532) Urinary potassium to creatinine ratio ( 30910378)	Alzheimer's disease in APOE e4- carriers ( 25778476) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 22412388) Inflammatory bowel disease ( 28067908 23128233) Perceived unattractiveness to mosquitoes ( 28199695) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		1 interacting genes: CYP2E1	3 interacting genes: PCMTD2 PHYH ZNF655
Entrez ID		2628	23305
HPRD ID		03838	09190
Ensembl ID		ENSG00000171766	ENSG00000164398
Uniprot IDs		A0A140VK19 P50440	B2RB13 B4DFW3 Q9UKU0
PDB IDs		1JDW 1JDX 2JDW 2JDX 3JDW 4JDW 5JDW 6JDW 7JDW 8JDW 9JDW
Enriched GO Terms of Interacting Partners?
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