GATM and CYP2E1

Data Source:
BioGRID (two hybrid)

		GATM	CYP2E1
Description		glycine amidinotransferase	cytochrome P450 family 2 subfamily E member 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Extracellular Exosome	Golgi Membrane Cytoplasm Mitochondrial Inner Membrane Endoplasmic Reticulum Membrane Intrinsic Component Of Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Amidinotransferase Activity Glycine Amidinotransferase Activity	Monooxygenase Activity Iron Ion Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen 4-nitrophenol 2-monooxygenase Activity Oxygen Binding Enzyme Binding Heme Binding Hsp70 Protein Binding Hsp90 Protein Binding Aromatase Activity
	Biological Process	Creatine Metabolic Process Creatine Biosynthetic Process Multicellular Organism Development Learning Or Memory Muscle Atrophy Positive Regulation Of Cold-induced Thermogenesis	Lipid Hydroxylation Organic Acid Metabolic Process Triglyceride Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Response To Bacterium Response To Ozone Response To Organonitrogen Compound Monoterpenoid Metabolic Process Drug Metabolic Process Carbon Tetrachloride Metabolic Process Benzene Metabolic Process 4-nitrophenol Metabolic Process Epoxygenase P450 Pathway Halogenated Hydrocarbon Metabolic Process Exogenous Drug Catabolic Process Long-chain Fatty Acid Biosynthetic Process Response To Ethanol Heterocycle Metabolic Process
Pathways		Creatine metabolism	Xenobiotics CYP2E1 reactions Biosynthesis of maresin-like SPMs
Drugs		Ornithine Glycine Delta-Amino Valeric Acid gamma-Aminobutyric acid Norvaline Alpha-Aminobutyric Acid	Diacerein
Diseases		Creatine deficiency syndrome, including: Arginine:glycine amidinotransferase deficiency (AGAT deficiency); Guanidinoacetate methyltransferase deficiency (GAMT deficiency); X-linked creatine deficiency syndrome (XL-CDS)
GWAS		Chronic kidney disease ( 31152163 26831199 20383146) Creatinine levels ( 31015462) Estimated glomerular filtration rate ( 31152163 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Homoarginine levels ( 24047826) Metabolite levels (small molecules and protein measures) ( 27005778) Phosphatidylcholine-ether levels ( 31551469) Renal function and chronic kidney disease ( 19430482) Serum metabolite levels ( 24625756) Urinary albumin-to-creatinine ratio ( 31511532) Urinary potassium to creatinine ratio ( 30910378)	Childhood body mass index ( 31752434) Coffee consumption ( 31046077) Gout ( 22179738) Obesity-related traits ( 23251661) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		1 interacting genes: CYP2E1	15 interacting genes: ABCA5 AGXT2 AMFR CLU CYB5A ECHS1 FANCG GATM LAMC3 MAFG NMI POR PTN RPL13A STUB1
Entrez ID		2628	1571
HPRD ID		03838	11813
Ensembl ID		ENSG00000171766	ENSG00000130649
Uniprot IDs		A0A140VK19 P50440	P05181
PDB IDs		1JDW 1JDX 2JDW 2JDX 3JDW 4JDW 5JDW 6JDW 7JDW 8JDW 9JDW	3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z
Enriched GO Terms of Interacting Partners?
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