GATM

Description		glycine amidinotransferase
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Extracellular Exosome
	Molecular Function	Protein Binding Amidinotransferase Activity Glycine Amidinotransferase Activity
	Biological Process	Creatine Metabolic Process Creatine Biosynthetic Process Multicellular Organism Development Learning Or Memory Muscle Atrophy Positive Regulation Of Cold-induced Thermogenesis
Pathways		Creatine metabolism
Drugs		Ornithine Glycine Delta-Amino Valeric Acid gamma-Aminobutyric acid Norvaline Alpha-Aminobutyric Acid
Diseases		Creatine deficiency syndrome, including: Arginine:glycine amidinotransferase deficiency (AGAT deficiency); Guanidinoacetate methyltransferase deficiency (GAMT deficiency); X-linked creatine deficiency syndrome (XL-CDS)
GWAS		Chronic kidney disease ( 31152163 26831199 20383146) Creatinine levels ( 31015462) Estimated glomerular filtration rate ( 31152163 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Homoarginine levels ( 24047826) Metabolite levels (small molecules and protein measures) ( 27005778) Phosphatidylcholine-ether levels ( 31551469) Renal function and chronic kidney disease ( 19430482) Serum metabolite levels ( 24625756) Urinary albumin-to-creatinine ratio ( 31511532) Urinary potassium to creatinine ratio ( 30910378)
Novel Interacting Genes		1 novel interacting genes: ACSL6
Interacting Genes		1 interacting genes: CYP2E1
Entrez ID		2628
HPRD ID		03838
Ensembl ID		ENSG00000171766
Uniprot IDs		A0A140VK19 P50440
PDB IDs		1JDW 1JDX 2JDW 2JDX 3JDW 4JDW 5JDW 6JDW 7JDW 8JDW 9JDW
Enriched GO Terms of Interacting Partners?
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