CYP2E1 and AGXT2

Data Source:
BioGRID (two hybrid)

		CYP2E1	AGXT2
Description		cytochrome P450 family 2 subfamily E member 1	alanine--glyoxylate aminotransferase 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Mitochondrial Inner Membrane Endoplasmic Reticulum Membrane Intrinsic Component Of Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle	Mitochondrion Mitochondrial Matrix
	Molecular Function	Monooxygenase Activity Iron Ion Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen 4-nitrophenol 2-monooxygenase Activity Oxygen Binding Enzyme Binding Heme Binding Hsp70 Protein Binding Hsp90 Protein Binding Aromatase Activity	Alanine-glyoxylate Transaminase Activity Pyridoxal Phosphate Binding (R)-3-amino-2-methylpropionate-pyruvate Transaminase Activity
	Biological Process	Lipid Hydroxylation Organic Acid Metabolic Process Triglyceride Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Response To Bacterium Response To Ozone Response To Organonitrogen Compound Monoterpenoid Metabolic Process Drug Metabolic Process Carbon Tetrachloride Metabolic Process Benzene Metabolic Process 4-nitrophenol Metabolic Process Epoxygenase P450 Pathway Halogenated Hydrocarbon Metabolic Process Exogenous Drug Catabolic Process Long-chain Fatty Acid Biosynthetic Process Response To Ethanol Heterocycle Metabolic Process	Glyoxylate Catabolic Process Glycine Biosynthetic Process, By Transamination Of Glyoxylate L-alanine Catabolic Process, By Transamination Positive Regulation Of Nitric Oxide Biosynthetic Process Glyoxylate Metabolic Process
Pathways		Xenobiotics CYP2E1 reactions Biosynthesis of maresin-like SPMs	Glyoxylate metabolism and glycine degradation Pyrimidine catabolism
Drugs		Diacerein	Pyridoxal phosphate Pyruvic acid Glycine Alanine
Diseases
GWAS		Childhood body mass index ( 31752434) Coffee consumption ( 31046077) Gout ( 22179738) Obesity-related traits ( 23251661) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Metabolite levels ( 21931564) Serum dimethylarginine levels (asymmetric/symetric ratio) ( 24159190) Symmetrical dimethylarginine levels ( 25245031 24159190) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Urinary metabolites ( 26352407 21572414) Urinary metabolites (H-NMR features) ( 24586186)
Interacting Genes		15 interacting genes: ABCA5 AGXT2 AMFR CLU CYB5A ECHS1 FANCG GATM LAMC3 MAFG NMI POR PTN RPL13A STUB1	2 interacting genes: ALDOB CYP2E1
Entrez ID		1571	64902
HPRD ID		11813	10638
Ensembl ID		ENSG00000130649	ENSG00000113492
Uniprot IDs		P05181	Q9BYV1
PDB IDs		3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z
Enriched GO Terms of Interacting Partners?
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