HIBCH and MFSD6

Data Source:
BioGRID (proximity labelling technology)

		HIBCH	MFSD6
Description		3-hydroxyisobutyryl-CoA hydrolase	major facilitator superfamily domain containing 6
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	3-hydroxyisobutyryl-CoA Hydrolase Activity	Protein Binding
	Biological Process	Valine Catabolic Process Branched-chain Amino Acid Catabolic Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Pathways		Branched-chain amino acid catabolism
Drugs		Quercetin
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Blood protein levels ( 30072576) Daytime sleep phenotypes ( 27126917) Lung cancer (SNP x SNP interaction) ( 24325914) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolites ( 26352407)	Arthritis (juvenile idiopathic) ( 33106285) Daytime sleep phenotypes ( 27126917) Estimated glomerular filtration rate ( 31015462) Medication use (thyroid preparations) ( 31015401) Platelet count ( 32888494)
Interacting Genes			36 interacting genes: ADIPOQ ALG8 APH1A APOL3 AQP7 C19orf18 CD79A CYB5R3 EBP ERGIC3 GJA8 GJB2 GPR152 GPR42 GPX8 LY6E MFSD4B NKG7 PDCD1LG2 SELENOK SGPL1 SHISAL1 SLC10A1 SLC10A6 SLC16A2 SLC18A1 SLC39A2 SMIM1 SSMEM1 STX12 SYNDIG1 TMEM179B TMEM237 TMEM242 TMEM258 TSPO2
Entrez ID		26275	54842
HPRD ID		11023	13369
Ensembl ID		ENSG00000198130	ENSG00000151690
Uniprot IDs		A0A140VJL0 Q6NVY1	Q6ZSS7
PDB IDs		3BPT
Enriched GO Terms of Interacting Partners?
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