ANXA7 and EXT2

Data Source:
BioGRID (two hybrid)

		ANXA7	EXT2
Description		annexin A7	exostosin glycosyltransferase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Membrane Chromaffin Granule Membrane Collagen-containing Extracellular Matrix Extracellular Exosome	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Integral Component Of Membrane UDP-N-acetylglucosamine Transferase Complex Extracellular Exosome
	Molecular Function	RNA Binding Integrin Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Calcium-dependent Protein Binding	Protein Binding Acetylglucosaminyltransferase Activity Glucuronosyltransferase Activity Transferase Activity, Transferring Glycosyl Groups Heparan Sulfate N-acetylglucosaminyltransferase Activity Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity
	Biological Process	Autophagy Negative Regulation Of Gene Expression Response To Organic Cyclic Compound Epithelial Cell Differentiation Response To Calcium Ion Membrane Fusion	Ossification Mesoderm Formation Glycosaminoglycan Biosynthetic Process Protein N-linked Glycosylation Signal Transduction Regulation Of Blood Pressure Gene Expression Heparan Sulfate Proteoglycan Biosynthetic Process Heparan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process Cell Differentiation Heparin Biosynthetic Process Cellular Polysaccharide Biosynthetic Process Fluid Transport Vasodilation Cellular Response To Fibroblast Growth Factor Stimulus Multicellular Organismal Water Homeostasis Sulfation Sodium Ion Homeostasis Heart Contraction Endochondral Bone Morphogenesis
Pathways			HS-GAG biosynthesis Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Drugs
Diseases			Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses Multiple exostoses
GWAS		Copper levels ( 26025379)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 28552196) Refractive error ( 32231278)
Interacting Genes		107 interacting genes: A1BG A2M ACTB ACTL6B ADAMTS10 ANGPT2 APC APLP1 ATP5F1B ATP6V1A ATXN3 BAG6 CCDC90B CCT7 CDK4 CELF3 CENPB CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE2 CPNE6 CRMP1 CSAD CTSB DDAH2 DMPK DOCK7 DVL1 DYNC1I1 EEF1A1 ERG28 EXT2 F13A1 FAF1 FBN3 FGB FLAD1 GAPDH GBP2 GDF9 GNB2 GNB5 HADHB HMGXB3 HOXD8 INPP5K INTS11 KLHL23 KMT2B LRIF1 MED31 MPPED1 MSH2 NGFR NMT2 NPRL2 OTUB1 PAAF1 PAX8 PDCD6 PDHB PKM PLD3 PRKACA PRKCA PRKCB PRKCG PRKG1 PSMB10 QARS1 RBBP4 RBM48 RPA1 RPL13 RPS2 S100A10 SDF4 SEMA5B SETDB1 SMPD1 SP110 SRC SRI SUMO3 TAF5L TIAM2 TLE1 TMEM108 TMSB4X TRMT2A TUBA1A TUBB2B TUBB3 UBE2D1 UCHL5 UNC119 USP4 VIM WDR18 WDR73 ZBTB16 ZNF135 ZNF431	10 interacting genes: ANXA7 CDKN1A EXT1 GALNT5 GSKIP PFDN1 SLC22A2 SMN1 TK1 TRAP1
Entrez ID		310	2132
HPRD ID		01720	00599
Ensembl ID		ENSG00000138279	ENSG00000151348
Uniprot IDs		B2R657 P20073	D3DR24 Q93063
PDB IDs
Enriched GO Terms of Interacting Partners?
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