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GAS8 and PNKP
Data Source:
BioGRID
(two hybrid)
GAS8
PNKP
Description
growth arrest specific 8
polynucleotide kinase 3'-phosphatase
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Apparatus
Cytosol
Microtubule
Plasma Membrane
Cilium
Axoneme
Motile Cilium
Ciliary Basal Body
Nucleus
Nucleoplasm
Nucleolus
Mitochondrion
Membrane
Molecular Function
Molecular_function
Protein Binding
Microtubule Binding
Damaged DNA Binding
Double-stranded DNA Binding
Endonuclease Activity
Protein Binding
ATP Binding
Purine Nucleotide Binding
Polynucleotide 3'-phosphatase Activity
ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity
Biological Process
Negative Regulation Of Cell Population Proliferation
Flagellated Sperm Motility
Cellular Protein Localization
Axoneme Assembly
Positive Regulation Of Smoothened Signaling Pathway
Cilium Movement Involved In Cell Motility
Positive Regulation Of Protein Localization To Cilium
Regulation Of Microtubule Binding
Nucleotide-excision Repair, DNA Damage Removal
DNA-dependent DNA Replication
DNA Repair
Response To Oxidative Stress
Response To Radiation
Negative Regulation Of Protein ADP-ribosylation
Dephosphorylation
Positive Regulation Of Telomere Maintenance Via Telomerase
DNA Damage Response, Detection Of DNA Damage
Nucleotide Phosphorylation
Positive Regulation Of Telomerase Activity
Nucleic Acid Phosphodiester Bond Hydrolysis
Polynucleotide 3' Dephosphorylation
Positive Regulation Of Telomere Capping
Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways
Activation of SMO
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs
Diseases
Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS
Brain morphology (MOSTest) (
32665545
)
Interacting Genes
111 interacting genes:
ARL6IP1
BCAR3
BHLHB9
BORCS6
BYSL
C1orf35
CARD10
CARD9
CBFA2T3
CCDC125
CCDC146
CCDC6
CCHCR1
CCNG1
CDC37
CDR2
CEP70
CFAP53
CINP
CKS1B
COG6
CPSF7
CRYBB1
CT45A1
CWF19L2
CYSRT1
DAXX
DDX17
DISC1
DMAP1
EAF1
EHHADH
EIF1AD
ERCC1
EVI5L
FAM161A
FAM161B
FHL2
GADD45GIP1
GCC1
GEM
GOLGA2
GRIPAP1
GSTA4
HEXIM2
HOMER3
HOMEZ
HOXA1
HSF2BP
IGFBP6
KDM1A
KRT14
KRT15
KRT16
KRT27
L3MBTL2
L3MBTL3
LASP1
LHX3
LMO1
LMO2
LZTS1
MAD1L1
MFAP1
MID2
MRFAP1L1
NDOR1
NKAPD1
PLK4
PNKP
PNMA5
POLR1C
POTEB3
PPFIA1
PRDM14
PRMT5
PRPF18
RALBP1
RBAK
RINT1
RUBCN
SCNM1
SKIL
SORBS3
SP7
SPATA18
SPG21
STAC3
TCEA2
THAP1
TNFAIP3
TRAF2
TRAF5
TRIM41
TRIM54
TSFM
TSGA10IP
TXLNA
TXLNB
USHBP1
YES1
YJU2
ZBTB22
ZBTB26
ZBTB39
ZNF212
ZNF250
ZNF572
ZNF620
ZNF629
ZNF792
49 interacting genes:
APP
CACFD1
CAMK2B
CARD10
CCDC14
CCDC43
CISD2
CNTROB
COL17A1
DVL3
FADS6
GAS8
GZMK
IKZF1
KANK2
KDM1A
KLHL12
KRTAP4-12
LMNA
MAGEA11
MCC
MEOX2
MGST2
MSANTD4
MYOZ1
OBI1
PICK1
PNMA5
POLB
PSTPIP1
RPRM
SFT2D1
SMAD5
SNX2
SP4
SUV39H1
SYNGR1
SYNGR3
SYP
TARBP2
TBC1D1
THAP1
TMEM239
TNIP1
TRIM37
XRCC1
XRCC4
ZBTB14
ZNF639
Entrez ID
2622
11284
HPRD ID
05533
09284
Ensembl ID
ENSG00000141013
ENSG00000039650
Uniprot IDs
A0A087WZT7
A0A384MR00
B7Z1U9
O95995
Q96T60
PDB IDs
2BRF
2W3O
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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