SENP3 and CDCA8

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		SENP3	CDCA8
Description		SUMO specific peptidase 3	cell division cycle associated 8
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm MLL1 Complex	Chromosome, Centromeric Region Nucleoplasm Nucleolus Cytosol Chromocenter Midbody Chromosome Passenger Complex Protein-containing Complex Intercellular Bridge Spindle Midzone
	Molecular Function	Protein Binding Cysteine-type Peptidase Activity SUMO-specific Protease Activity	Protein Binding
	Biological Process	RRNA Processing Protein Desumoylation	Mitotic Sister Chromatid Segregation Mitotic Metaphase Plate Congression Chromosome Organization Cell Division
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) IgM levels ( 23118916) Refractive error ( 32231278)	Axial length ( 24144296) Eyebrow thickness ( 26926045)
Interacting Genes		18 interacting genes: ADRB2 ATF7IP BECN1 CDCA8 CDK4 CDK6 CEP19 DNM1L EP300 HIC1 MDM2 NPM1 PARP1 SUMO2 TRIM54 TRIM63 USP15 USP21	26 interacting genes: AURKB BIRC5 EMILIN1 FBXO17 GYS1 H3C14 HLA-DRB3 HMBOX1 INCENP MAPKAPK5 NEK3 NKAPD1 NTAQ1 PIAS2 PIH1D2 RANBP2 RPRD1B SENP3 SET SGO1 SGO2 SNAPC5 SPANXN2 TTK UBE2I ZNF277
Entrez ID		26168	55143
HPRD ID		08339	13017
Ensembl ID		ENSG00000161956	ENSG00000134690
Uniprot IDs		Q9H4L4	Q53HL2
PDB IDs			2KDD 2QFA 2RAW 2RAX 6YIE 6YIF 6YIH
Enriched GO Terms of Interacting Partners?
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