SENP3 and HIC1

Data Source:
BioGRID (enzymatic study)

		SENP3	HIC1
Description		SUMO specific peptidase 3	HIC ZBTB transcriptional repressor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm MLL1 Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	Protein Binding Cysteine-type Peptidase Activity SUMO-specific Protease Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	RRNA Processing Protein Desumoylation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol	SUMOylation of transcription factors
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) IgM levels ( 23118916) Refractive error ( 32231278)	Brain morphology (MOSTest) ( 32665545) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Platelet count ( 27863252) Plateletcrit ( 32888494 27863252)
Interacting Genes		18 interacting genes: ADRB2 ATF7IP BECN1 CDCA8 CDK4 CDK6 CEP19 DNM1L EP300 HIC1 MDM2 NPM1 PARP1 SUMO2 TRIM54 TRIM63 USP15 USP21	12 interacting genes: ARID1A CRBN CTBP1 CTBP2 HDAC1 HIC2 MECOM PIAS1 SENP3 SIRT1 TCF7L2 UBE2I
Entrez ID		26168	3090
HPRD ID		08339	04826
Ensembl ID		ENSG00000161956	ENSG00000177374
Uniprot IDs		Q9H4L4	A0PJI1 Q14526
PDB IDs
Enriched GO Terms of Interacting Partners?
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