HIC1 and MECOM

Data Source:
BioGRID (fluorescent resonance energy transfer)

		HIC1	MECOM
Description		HIC ZBTB transcriptional repressor 1	MDS1 and EVI1 complex locus
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Histone Deacetylase Complex Nucleus Nucleoplasm Cytosol Nuclear Speck
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding Histone Methyltransferase Activity (H3-K9 Specific)
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Cell Differentiation Negative Regulation Of Programmed Cell Death Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Histone H3-K9 Methylation Regulation Of Cell Cycle Heterochromatin Organization Hematopoietic Stem Cell Proliferation
Pathways		SUMOylation of transcription factors	PKMTs methylate histone lysines Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases			Chronic myeloid leukemia (CML)
GWAS		Brain morphology (MOSTest) ( 32665545) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Platelet count ( 27863252) Plateletcrit ( 32888494 27863252)	Aging (time to event) ( 21782286) Asthma ( 32296059) Blood pressure ( 21909110) Blood pressure (smoking interaction) ( 25189868) Blood urea nitrogen levels ( 31152163 29403010) Bone mineral density (lumbar spine) in inflammatory bowel disease ( 29603369) Calcific aortic valve stenosis ( 32141789) Childhood and early adolescence aggressive behavior ( 26087016) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 27841878 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Estimated glomerular filtration rate ( 31152163 31015462) FEV1 ( 30804560) Glaucoma ( 30054594) Glomerular filtration rate ( 29403010) Gut microbiota relative abundance (Ruminococcus belonging to family Erysipelotrichaceae) ( 33208821) Height ( 31562340) Hematocrit ( 32888494 27863252) Hematology traits ( 30576415) Hemoglobin ( 32888494) Intraocular pressure ( 29617998 29785010 31959993 30054594) Joint damage in rheumatoid arthritis ( 31596875) Late-onset Alzheimer's disease ( 27770636) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antiglaucoma preparations and miotics) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Monocyte percentage of white cells ( 32888494) Myeloproliferative neoplasms ( 25849990 33057200) Nasopharyngeal carcinoma ( 26545403) Osteoporosis ( 23349225) Phoneme awareness ( 30741946) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Prostate cancer ( 29892016) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Red blood cell count ( 32888494 27863252) Renal function-related traits (BUN) ( 22797727) Response to fenofibrate (triglyceride levels) ( 27002377) Systolic blood pressure ( 27841878 21909115 28739976 27618447 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Total intracranial volume ( 31530798) Urate levels ( 31578528) White blood cell count ( 32888494)
Interacting Genes		12 interacting genes: ARID1A CRBN CTBP1 CTBP2 HDAC1 HIC2 MECOM PIAS1 SENP3 SIRT1 TCF7L2 UBE2I	16 interacting genes: CLIC3 CREBBP CTBP1 CTBP2 HDAC1 HDAC4 HIC1 KAT2B MBD3 PIK3R3 PRMT1 SMAD1 SMAD2 SMAD3 SMAD4 UBE2I
Entrez ID		3090	2122
HPRD ID		04826	01310
Ensembl ID		ENSG00000177374	ENSG00000085276
Uniprot IDs		A0PJI1 Q14526	A0A0C3SFZ7 C7FEN9 Q03112
PDB IDs			6BW3
Enriched GO Terms of Interacting Partners?
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