CCDC69 and MAP3K20

Data Source:
BioGRID (two hybrid)

		CCDC69	MAP3K20
Description		coiled-coil domain containing 69	mitogen-activated protein kinase kinase kinase 20
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Midbody Spindle Midzone	Nucleus Cytoplasm Cytosol
	Molecular Function	Microtubule Binding	Magnesium Ion Binding RNA Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding
	Biological Process	Spindle Midzone Assembly	DNA Damage Checkpoint Activation Of MAPKK Activity Protein Phosphorylation Cytoskeleton Organization Cell Cycle Arrest Activation Of JUN Kinase Activity Cell Death Cell Differentiation Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Stress-activated MAPK Cascade Limb Development Cellular Response To Gamma Radiation Positive Regulation Of Mitotic DNA Damage Checkpoint
Pathways
Drugs			Dasatinib Fostamatinib
Diseases
GWAS		Bulimia nervosa ( 23568457) Chronic obstructive pulmonary disease ( 30804561) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Loneliness (linear analysis) ( 27629369) Lymphocyte counts ( 32888494) Monocyte count ( 32888494 27863252) Neutrophil count ( 32888494) Obesity-related traits ( 23251661) Red cell distribution width ( 32888494) White blood cell count ( 32888494 27863252)
Interacting Genes		5 interacting genes: ACO1 MAP3K1 MAP3K20 PSMA3 SMURF1	32 interacting genes: CCDC69 CRMP1 DDAH2 EZH2 IGHM ITSN1 MAP2K4 MAP2K6 MAP2K7 MIDN MPP1 NEDD4L RBX1 RNF19A RPS6KA5 SMARCB1 SRPK2 TGFBR1 UNC119 VPS33B YWHAG YWHAZ ZFP1 ZFP2 ZNF33A ZNF35 ZNF567 ZNF593 ZNF660 ZNF71 ZNF746 ZNF775
Entrez ID		26112	51776
HPRD ID		13152	11791
Ensembl ID		ENSG00000198624	ENSG00000091436
Uniprot IDs		A6NI79 Q7L2X4	D4Q8H0 Q9NYL2
PDB IDs			5HES 5X5O 6JUT 6JUU
Enriched GO Terms of Interacting Partners?
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