IBTK and PDCD4

Data Source:
BioGRID (pull down)

		IBTK	PDCD4
Description		inhibitor of Bruton tyrosine kinase	programmed cell death 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Membrane	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Kinase Binding Protein Tyrosine Kinase Inhibitor Activity	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Protein Tyrosine Kinase Activity	Apoptotic Process Cell Aging BMP Signaling Pathway Interleukin-12-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Inflammatory Response Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Cellular Response To Lipopolysaccharide Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Myofibroblast Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways			Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs
Diseases
GWAS		Central corneal thickness ( 31798171 29760442) Corneal structure ( 23291589) Coronary artery disease ( 33020668) Intraocular pressure ( 29617998 29235454)	Fish- and plant-related diet ( 32066663)
Interacting Genes		6 interacting genes: BTK LAMTOR3 PDCD4 PPP1CA PRKCB PRKD1	16 interacting genes: APOE BTRC CSNK2A1 EIF4A2 EIF4A3 EIF4G1 IBTK LRRK1 PSEN1 PSEN2 RPL5 RPLP1 RPS13 RPS6KA1 SKP2 SUMO2
Entrez ID		25998	27250
HPRD ID		12105	10549
Ensembl ID		ENSG00000005700	ENSG00000150593
Uniprot IDs		B7ZLE0 E7EPI0 Q9P2D0	B4DKX4 Q53EL6
PDB IDs			2GGF 2KZT 2RG8 2ZU6 3EIJ
Enriched GO Terms of Interacting Partners?
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