DIP2A and PTPN3

Data Source:
BioGRID (two hybrid)

		DIP2A	PTPN3
Description		disco interacting protein 2 homolog A	protein tyrosine phosphatase non-receptor type 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Cell Surface Membrane Dendritic Spine	Cytoplasm Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Acetate-CoA Ligase Activity Protein Binding	Phosphotyrosine Residue Binding Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Sodium Channel Regulator Activity ATPase Binding
	Biological Process	Acetyl-CoA Biosynthetic Process Negative Regulation Of Gene Expression Dendritic Spine Morphogenesis Positive Regulation Of Peptidyl-lysine Acetylation	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Membrane Protein Ectodomain Proteolysis Liver Regeneration Regulation Of Membrane Depolarization During Action Potential Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways			EGFR downregulation Negative regulation of MAPK pathway
Drugs
Diseases
GWAS		Anti-saccade response ( 29064472) Lymphocyte counts ( 32888494 27863252) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Pulse pressure ( 30224653) White blood cell count ( 32888494)	Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) HIV-associated neurocognitive disorder ( 28447399) HIV-associated neurocognitive disorder (asymptomatic neurocogntive impairment) ( 28447399) HIV-associated neurocognitive disorder (mild neurocognitive disorder or asymptomatic neurocognitive impairment) ( 28447399) Iris color (a* coordinate) ( 30895295) Iris color (b* coordinate) ( 30895295) Red blood cell density in sickle cell anemia ( 28552477) Serum albumin level ( 29403010) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Triglyceride levels ( 32203549)
Interacting Genes		19 interacting genes: ADAMTSL4 CCDC33 CEP44 DAB2 DLX2 FAM214B GPATCH2L IQUB JMJD6 MBIP PSME3 PTPN3 SORBS3 STAC3 TLE5 TMCC2 TRIM39 TRIP13 ZBTB43	26 interacting genes: ADAM17 AKR1C1 AKT1 CD247 DIP2A GHR HSPB1 LMO1 MAPK12 MLH1 MTMR9 NXT2 PLEKHF2 RNF111 RPS6KA1 TENT5D TFAP4 TRIM41 VCP VWA2 WDR6 YWHAB YWHAG YWHAQ ZAP70 ZCCHC10
Entrez ID		23181	5774
HPRD ID		07611	06767
Ensembl ID		ENSG00000160305	ENSG00000070159
Uniprot IDs		Q14689 Q96NX2	B7Z3V3 B7Z9V1 B7ZA03 P26045 Q8N4S3
PDB IDs			2B49 4QUM 4QUN 4RH5 4RH9 4RHG 4RI4 4RI5 4S0G 6HKS
Enriched GO Terms of Interacting Partners?
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