ARIH1 and EIF4E2

Data Source:
BioGRID (two hybrid)
HPRD (in vitro, two hybrid, in vivo)

		ARIH1	EIF4E2
Description		ariadne RBR E3 ubiquitin protein ligase 1	eukaryotic translation initiation factor 4E family member 2
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Cajal Body Nuclear Body SCF Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Lewy Body	P-body Cytoplasm Cytosol MRNA Cap Binding Complex Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Ubiquitin Protein Ligase Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Phosphopantetheinylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Translational Initiation Negative Regulation Of Translation Gene Silencing By RNA Positive Regulation Of MiRNA Mediated Inhibition Of Translation
Pathways		ISG15 antiviral mechanism	ISG15 antiviral mechanism
Drugs
Diseases
GWAS			Height ( 25282103) Non-small cell lung cancer (survival) ( 21079520) Refractive error ( 32231278)
Interacting Genes		17 interacting genes: CCNE1 CDKN1B CRY1 DCUN1D1 EIF4E2 HSPB1 PLD1 RBX1 SEC31A UBC UBE2D1 UBE2D3 UBE2E2 UBE2L3 UBE2L6 UBE2N VAV2	45 interacting genes: ADAMTSL4 AMOTL2 APP ARIH1 CARD9 CBY2 CDR2 EIF4EBP1 EIF4EBP3 EIF4ENIF1 FBXO25 GIGYF1 HOMEZ KRT13 KRT19 KRT20 KRT31 KRT40 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-12 LZTS2 MAGED1 MAPRE3 MDFI MGAT5B MIPOL1 MYOG NECAB2 NOTCH2NLA PRDM14 REL SPAG5 SPRY2 TADA2A TCF4 TLE5 TMCC2 TRIM27 TRIM54 UBXN11 USHBP1 USP54 ZBTB9
Entrez ID		25820	9470
HPRD ID		05730	05798
Ensembl ID		ENSG00000166233	ENSG00000135930
Uniprot IDs		Q9Y4X5	B8ZZ50 B8ZZL3 B9A023 O60573 Q53RG0 Q59FE1
PDB IDs		1WD2 2M9Y 4KBL 4KC9 5TTE 5UDH	2JGB 2JGC 5NVK 5NVL 5NVM 5NVN 5XLN
Enriched GO Terms of Interacting Partners?
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