SUN2 and RGS2

Data Source:
BioGRID (affinity chromatography technology)

		SUN2	RGS2
Description		Sad1 and UNC84 domain containing 2	regulator of G protein signaling 2
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Condensed Nuclear Chromosome Nuclear Envelope Integral Component Of Nuclear Inner Membrane Endosome Membrane Nuclear Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex	Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Neuron Projection
	Molecular Function	Protein Binding Lamin Binding Microtubule Binding Identical Protein Binding Protein-membrane Adaptor Activity Cytoskeleton-nuclear Membrane Anchor Activity	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Protein Binding Calmodulin Binding Beta-tubulin Binding
	Biological Process	Nuclear Envelope Organization Mitotic Spindle Organization Nuclear Migration Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Positive Regulation Of Cell Migration Nuclear Migration Along Microfilament Meiotic Cell Cycle Centrosome Localization Nuclear Matrix Anchoring At Nuclear Membrane	Response To Amphetamine Cell Cycle G Protein-coupled Receptor Signaling Pathway Spermatogenesis Brain Development Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Phospholipase Activity Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Neuron Projection Development Negative Regulation Of Translation Ovulation Negative Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Negative Regulation Of CAMP-mediated Signaling Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Brown Fat Cell Differentiation Relaxation Of Cardiac Muscle Relaxation Of Vascular Associated Smooth Muscle Maternal Process Involved In Female Pregnancy Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Glycine Import Across Plasma Membrane
Pathways		Meiotic synapsis	G alpha (q) signalling events
Drugs
Diseases
GWAS		Heel bone mineral density ( 28869591) Prostate cancer ( 31562322) Resting heart rate ( 27798624) Sleep duration ( 30846698)	Coronary artery calcification ( 23870195) Response to quetiapine in schizophrenia ( 29503163)
Interacting Genes		4 interacting genes: HGS NRM RAB5B RPS20	61 interacting genes: ADCY5 ADRA1A ADRB2 ARFGAP1 BBS10 CALM1 CEP126 CHD3 CIAO1 CLTA COMT COPB1 COPB2 CRMP1 CTSB DDR1 DUSP21 DYNLL1 EGFR EIF3L FZD5 GDE1 GIT1 GNA15 GNAI3 GNAQ GNAS HAUS5 HSPA8 IER3IP1 KLK8 LIG1 LRFN1 MARCHF6 METTL18 MON1A MTUS2 NINL NIPSNAP1 PPP1R9B PRKCA PRKCB PRKCG PRKCSH PRKG1 PRKN RAB2A RABAC1 RAP1B REEP5 RIN3 SCN5A TSPAN15 TUBB2B UBC VPS29 WDR74 XRCC6 ZBTB48 ZNF579 ZYX
Entrez ID		25777	5997
HPRD ID		15611	02917
Ensembl ID		ENSG00000100242	ENSG00000116741
Uniprot IDs		A0A024R1P7 B4E2A6 Q9UH99	A0A024R939 P41220
PDB IDs		3UNP 4DXR 4DXS 4DXT 4FI9	2AF0 2V4Z 4EKC 4EKD
Enriched GO Terms of Interacting Partners?
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