SYCE2 and TRIM69

Data Source:
BioGRID (two hybrid)

		SYCE2	TRIM69
Description		synaptonemal complex central element protein 2	tripartite motif containing 69
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GO Annotations	Cellular Component	Central Element Nucleoplasm Chromosome	Nucleus Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Synaptonemal Complex Assembly Cell Division	Protein Polyubiquitination Apoptotic Process Protein Ubiquitination
Pathways		Meiotic synapsis	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494)	Estimated glomerular filtration rate in non-diabetics ( 31451708)
Interacting Genes		13 interacting genes: CCDC196 CDC37 GAD2 HOMER1 IFT20 KIFC3 MED11 MED4 NAP1L5 TEX12 TRIM69 TRIML2 TSNAX	53 interacting genes: AIFM2 APP ASNS ATP5MC1 BEX2 BIN3 C4orf45 CDSN DVL1 ETFDH FAM110A FAM161A FAM90A1 FKBP1B GEM HAUS1 HGS IYD KLHL38 KRT17 LARP1B LYSMD1 MAGEA4 MAJIN MED20 MID2 NEK8 NTAQ1 PML POLR3K PPP1R18 RECK RINT1 RSPH14 SF1 SF3A3 SKIL STMN3 SYCE2 SYNE4 TNNT2 TRIM44 TRIM54 TRIM55 TRIM63 UBE2D1 UBE2D3 UBE2E1 UBE2H UBE2N WASHC1 WWOX ZNF483
Entrez ID		256126	140691
HPRD ID		19522	11518
Ensembl ID		ENSG00000161860	ENSG00000185880
Uniprot IDs		Q6PIF2	H0YL66 Q86WT6
PDB IDs		6R17	4NQJ 6YXE
Enriched GO Terms of Interacting Partners?
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