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NUTM1 and ALOX5
Data Source:
BioGRID
(two hybrid, two hybrid)
NUTM1
ALOX5
Description
NUT midline carcinoma family member 1
arachidonate 5-lipoxygenase
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Extracellular Region
Extracellular Space
Nuclear Envelope
Nuclear Envelope Lumen
Nucleoplasm
Cytosol
Nuclear Matrix
Nuclear Membrane
Secretory Granule Lumen
Perinuclear Region Of Cytoplasm
Ficolin-1-rich Granule Lumen
Molecular Function
Protein Binding
Arachidonate 5-lipoxygenase Activity
Iron Ion Binding
Protein Binding
Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen
Hydrolase Activity
Biological Process
Negative Regulation Of Endothelial Cell Proliferation
Leukocyte Chemotaxis Involved In Inflammatory Response
Leukocyte Migration Involved In Inflammatory Response
Leukotriene Production Involved In Inflammatory Response
Leukotriene Metabolic Process
Humoral Immune Response
Negative Regulation Of Angiogenesis
Cytokine-mediated Signaling Pathway
Arachidonic Acid Metabolic Process
Leukotriene Biosynthetic Process
Lipoxygenase Pathway
Positive Regulation Of Bone Mineralization
Lipid Oxidation
Interleukin-18-mediated Signaling Pathway
Dendritic Cell Migration
Glucose Homeostasis
Long-chain Fatty Acid Biosynthetic Process
Neutrophil Degranulation
Linoleic Acid Metabolic Process
Regulation Of Fat Cell Differentiation
Regulation Of Inflammatory Response
Negative Regulation Of Inflammatory Response
Regulation Of Insulin Secretion
Hepoxilin Biosynthetic Process
Negative Regulation Of Vascular Wound Healing
Negative Regulation Of Wound Healing
Regulation Of Inflammatory Response To Wounding
Regulation Of Cytokine Production Involved In Inflammatory Response
Regulation Of Cellular Response To Oxidative Stress
Leukotriene A4 Biosynthetic Process
Regulation Of Reactive Oxygen Species Biosynthetic Process
Negative Regulation Of Response To Endoplasmic Reticulum Stress
Negative Regulation Of Sprouting Angiogenesis
Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell
Lipoxin Biosynthetic Process
Pathways
Synthesis of 5-eicosatetraenoic acids
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Synthesis of Lipoxins (LX)
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
Interleukin-18 signaling
Biosynthesis of D-series resolvins
Biosynthesis of maresins
Biosynthesis of E-series 18(S)-resolvins
Biosynthesis of aspirin-triggered D-series resolvins
Biosynthesis of E-series 18(R)-resolvins
Biosynthesis of DPAn-3-derived protectins and resolvins
Biosynthesis of DPAn-3-derived maresins
Biosynthesis of DPAn-3-derived 13-series resolvins
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
Drugs
Vitamin E
Masoprocol
Aminosalicylic acid
Mesalazine
Montelukast
Diethylcarbamazine
Zileuton
Sulfasalazine
Meclofenamic acid
Balsalazide
Minocycline
Hyperforin
Resveratrol
Licofelone
MLN-977
Morniflumate
Diacerein
Fostamatinib
Rhein
alpha-Tocopherol succinate
D-alpha-Tocopherol acetate
Diseases
GWAS
Cholesterol, total (
24097068
)
HDL cholesterol (
24097068
)
HDL cholesterol levels (
28334899
)
Immature fraction of reticulocytes (
32888494
)
Mean corpuscular hemoglobin (
32888494
20139978
)
Mean corpuscular volume (
20139978
)
Total cholesterol levels (
28334899
)
Interacting Genes
54 interacting genes:
ALOX5
AQP1
ARHGEF6
AXIN1
C2CD6
CCDC116
CCDC185
CCHCR1
CDC20B
CDK18
CHCHD3
ENKD1
FAM161A
GADD45GIP1
GPANK1
HSPBAP1
IFIT2
KANK2
KANSL1
KPNA2
LHX8
LMO1
LMO2
LMO3
LRRC8E
MBD3
METTL17
MORN4
NEBL
OSTF1
P4HA3
PLEKHF2
PRKAA2
PRKAB2
PRPF18
PSME4
RCOR3
RIC8A
SAMD4A
SAMD4B
SCNM1
SH2D1B
SH2D4A
SMARCD1
SOGA1
TBC1D21
TEAD4
TLE5
TP53BP2
TSGA10IP
TTC23
TXN2
ZMYND10
ZNF277
27 interacting genes:
ACTB
ALOX5AP
ALPL
APP
C10orf67
CCDC174
CEP57L1
CEP63
COTL1
DICER1
GATC
GRB2
HHIPL2
HSD17B1
LCN1
LTC4S
MAD1L1
MAPKAPK2
MEOX1
MEOX2
MTDH
NUTM1
OOEP
REL
SYCE1
TBC1D7
TGFBRAP1
Entrez ID
256646
240
HPRD ID
10606
01065
Ensembl ID
ENSG00000184507
ENSG00000012779
Uniprot IDs
Q86Y26
P09917
PDB IDs
2ABV
3O8Y
3V92
3V98
3V99
6N2W
6NCF
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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