EPGN and CXCL9

Data Source:
BioGRID (two hybrid)

		EPGN	CXCL9
Description		epithelial mitogen	C-X-C motif chemokine ligand 9
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Integral Component Of Plasma Membrane Clathrin-coated Vesicle Membrane	Extracellular Region Extracellular Space External Side Of Plasma Membrane
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Cytokine Activity Protein Binding Chemokine Activity CXCR Chemokine Receptor Binding CXCR3 Chemokine Receptor Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Angiogenesis Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Kinase B Signaling Membrane Organization	Chemotaxis Defense Response Inflammatory Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Neutrophil Chemotaxis Regulation Of Cell Population Proliferation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Positive Regulation Of Myoblast Fusion
Pathways		PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Breast size ( 22747683) Immune reponse to smallpox (secreted IL-1beta) ( 22610502)	Blood protein levels ( 28240269) Hippocampal volume ( 29274321) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)
Interacting Genes		4 interacting genes: ADAM33 CXCL9 MTIF3 TIMMDC1	76 interacting genes: AMIGO1 AQP6 ATP1B4 BMF BSCL2 BTNL9 C16orf92 CCL11 CCL13 CCL2 CCL21 CCL26 CCL28 CCL5 CCR3 CD33 CHODL CLDN2 CLDN5 CLDN7 CLEC17A CLEC2D CLEC4E CLEC7A CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCR3 DPP4 EPGN EREG FBXO7 FCGR2A FFAR2 FNDC9 FUT7 GJB1 GORAB GPR42 IFNGR2 ITM2C KASH5 KIR2DL3 LDLRAD1 LEUTX LRRC25 LSMEM2 MR1 MTIF3 MUC1 NEMP1 PAX8 PF4 PPBP PTPN5 RHCG SFTPC SLC10A1 SLC39A1 SSMEM1 SUSD3 SYNE4 TM4SF18 TMED5 TMEM106C TMEM234 TMEM237 TMEM31 TMPRSS2 TNFSF14 TNFSF8 TSPAN18 XCL1
Entrez ID		255324	4283
HPRD ID		10866	03416
Ensembl ID		ENSG00000182585	ENSG00000138755
Uniprot IDs		Q6UW88	Q07325
PDB IDs		5WB8
Enriched GO Terms of Interacting Partners?
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