CNIH2 and HIBADH

Data Source:
BioGRID (two hybrid)

		CNIH2	HIBADH
Description		cornichon family AMPA receptor auxiliary protein 2	3-hydroxyisobutyrate dehydrogenase
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane ER To Golgi Transport Vesicle Membrane Postsynaptic Density Dendrite AMPA Glutamate Receptor Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Dendritic Spine Dendritic Shaft Synapse Postsynaptic Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane	Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding	Protein Binding 3-hydroxyisobutyrate Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor NADP Binding NAD Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential COPII Vesicle Coating Localization Within Membrane Regulation Of Postsynaptic Neurotransmitter Receptor Activity Negative Regulation Of Receptor Localization To Synapse Negative Regulation Of Anterograde Synaptic Vesicle Transport Regulation Of NMDA Receptor Activity Regulation Of AMPA Receptor Activity	Valine Catabolic Process Branched-chain Amino Acid Catabolic Process
Pathways		COPII-mediated vesicle transport Cargo concentration in the ER	Branched-chain amino acid catabolism
Drugs			NADH
Diseases
GWAS		Bipolar disorder ( 21926972 31043756) Insomnia ( 32332799) Urate levels ( 31578528)	Alcohol consumption (drinks per week) ( 30643258) Asthma ( 31959851) Diastolic blood pressure ( 27841878) General risk tolerance (MTAG) ( 30643258) Kidney stones ( 31729369) Lead levels in blood ( 25820613) Pulse pressure ( 27841878) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Systolic blood pressure ( 27841878)
Interacting Genes		6 interacting genes: CD53 CREB3L1 GORAB HIBADH TMEM14B TMPRSS2	39 interacting genes: ADAM33 AGTRAP AIG1 AMELY AQP3 ASGR1 BRCA1 C2CD2L CDS2 CLEC2A CMTM7 CNIH2 COMT CTSA EFNA5 ERMP1 GOSR2 MAL NDUFB11 PAEP PLN PRAF2 PTCH1 RTP2 SCARB2 SEC22B SFT2D2 SNORC TFRC TM6SF2 TMEM14B TMEM222 TMEM60 TMEM86B TRIM63 UBIAD1 VAMP2 VAMP5 ZFPL1
Entrez ID		254263	11112
HPRD ID		13078	12238
Ensembl ID		ENSG00000174871	ENSG00000106049
Uniprot IDs		Q6PI25	A0A024RA75 P31937
PDB IDs			2GF2 2I9P
Enriched GO Terms of Interacting Partners?
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