FRZB and BBS10

Data Source:
BioGRID (two hybrid)

		FRZB	BBS10
Description		frizzled related protein	Bardet-Biedl syndrome 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Membrane	Cilium
	Molecular Function	Protein Binding Wnt-protein Binding	RNA Polymerase II Repressing Transcription Factor Binding Protein Binding ATP Binding
	Biological Process	Skeletal System Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Development Neural Crest Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Convergent Extension Involved In Organogenesis Canonical Wnt Signaling Pathway Negative Regulation Of Cartilage Development Somite Development Negative Regulation Of Hepatocyte Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis	Visual Perception Regulation Of Protein-containing Complex Assembly Photoreceptor Cell Maintenance Response To Stimulus Chaperone-mediated Protein Complex Assembly Non-motile Cilium Assembly
Pathways			BBSome-mediated cargo-targeting to cilium
Drugs
Diseases			Bardet-Biedl syndrome (BBS)
GWAS		Blood protein levels ( 30072576 29875488 28240269) Heel bone mineral density ( 30598549 28869591) Neurological blood protein biomarker levels ( 31320639) Night sleep phenotypes ( 27126917) Waist-to-hip circumference ratio (dietary energy interaction) ( 23192594) Working memory ( 31598132)
Interacting Genes		8 interacting genes: BBS10 CYSRT1 EHF ELF5 PNO1 POLA2 RBX1 SMAD1	12 interacting genes: CSNK1E FRZB HDAC6 MAP3K7 MAPK6 MAPK8IP2 NR4A1 PTK2 RASA1 RGS2 TNFSF11 YAE1
Entrez ID		2487	79738
HPRD ID		07282	08036
Ensembl ID		ENSG00000162998	ENSG00000179941
Uniprot IDs		D9ZGF6 Q92765	Q8TAM1
PDB IDs
Enriched GO Terms of Interacting Partners?
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