CLEC5A and TYROBP

Data Source:
HPRD (in vivo, in vitro)

		CLEC5A	TYROBP
Description		C-type lectin domain containing 5A	transmembrane immune signaling adaptor TYROBP
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Specific Granule Membrane Tertiary Granule Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Secretory Granule Membrane
	Molecular Function	Virus Receptor Activity Carbohydrate Binding	Signaling Receptor Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Osteoblast Development Cellular Defense Response Signal Transduction Negative Regulation Of Apoptotic Process Neutrophil Degranulation Innate Immune Response Viral Entry Into Host Cell	Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway Stimulatory C-type Lectin Receptor Signaling Pathway Myeloid Leukocyte Activation Microglial Cell Activation Involved In Immune Response Neutrophil Activation Involved In Immune Response Cellular Defense Response Signal Transduction Positive Regulation Of Gene Expression Actin Cytoskeleton Organization Osteoclast Differentiation Negative Regulation Of B Cell Proliferation Forebrain Development Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Negative Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Macrophage Fusion Intracellular Signal Transduction Apoptotic Cell Clearance Neutrophil Degranulation Innate Immune Response Response To Axon Injury Regulation Of Immune Response Protein Stabilization Apoptotic Signaling Pathway Positive Regulation Of Hippocampal Neuron Apoptotic Process Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Neuron Death Positive Regulation Of Receptor Localization To Synapse Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Protein Localization To Cell Surface Positive Regulation Of Osteoclast Development
Pathways		DAP12 interactions Neutrophil degranulation	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 interactions DAP12 signaling DAP12 signaling Signal regulatory protein family interactions Other semaphorin interactions Neutrophil degranulation
Drugs
Diseases			Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); Nasu-Hakola disease
GWAS		Anorexia nervosa ( 23568457) Compulsion score in obsessive compulsive disorder ( 32063569)
Interacting Genes		1 interacting genes: TYROBP	15 interacting genes: CD300E CLEC5A KIR3DS1 KLRC3 KLRC4 KLRK1 NCR2 SIGLEC14 SIRPB1 SLC35B4 SYK TMEM86A TREM1 TREM2 ZAP70
Entrez ID		23601	7305
HPRD ID		09229	04996
Ensembl ID		ENSG00000258227	ENSG00000011600
Uniprot IDs		A4D1U7 Q14DL9 Q9NY25	O43914 X6RGC9
PDB IDs		2YHF	2L34 2L35 4WO1 4WOL
Enriched GO Terms of Interacting Partners?
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