TYROBP and SIRPB1

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		TYROBP	SIRPB1
Description		transmembrane immune signaling adaptor TYROBP	signal regulatory protein beta 1
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Secretory Granule Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Secretory Granule Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	Protein Binding
	Biological Process	Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway Stimulatory C-type Lectin Receptor Signaling Pathway Myeloid Leukocyte Activation Microglial Cell Activation Involved In Immune Response Neutrophil Activation Involved In Immune Response Cellular Defense Response Signal Transduction Positive Regulation Of Gene Expression Actin Cytoskeleton Organization Osteoclast Differentiation Negative Regulation Of B Cell Proliferation Forebrain Development Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Negative Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Macrophage Fusion Intracellular Signal Transduction Apoptotic Cell Clearance Neutrophil Degranulation Innate Immune Response Response To Axon Injury Regulation Of Immune Response Protein Stabilization Apoptotic Signaling Pathway Positive Regulation Of Hippocampal Neuron Apoptotic Process Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Neuron Death Positive Regulation Of Receptor Localization To Synapse Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Protein Localization To Cell Surface Positive Regulation Of Osteoclast Development	Signal Transduction Cell Surface Receptor Signaling Pathway Neutrophil Degranulation Innate Immune Response Positive Regulation Of Phagocytosis Positive Regulation Of T Cell Activation
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 interactions DAP12 signaling DAP12 signaling Signal regulatory protein family interactions Other semaphorin interactions Neutrophil degranulation	DAP12 interactions Signal regulatory protein family interactions Neutrophil degranulation
Drugs
Diseases		Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); Nasu-Hakola disease
GWAS			Blood protein levels ( 30072576 29875488) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494 27863252) Metabolite levels ( 23823483) Neutrophil count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Systemic lupus erythematosus ( 33536424) White blood cell count ( 32888494)
Interacting Genes		15 interacting genes: CD300E CLEC5A KIR3DS1 KLRC3 KLRC4 KLRK1 NCR2 SIGLEC14 SIRPB1 SLC35B4 SYK TMEM86A TREM1 TREM2 ZAP70	7 interacting genes: APOC1 BPIFA1 DAB1 MEOX2 RBFOX1 RBPMS TYROBP
Entrez ID		7305	10326
HPRD ID		04996	04866
Ensembl ID		ENSG00000011600	ENSG00000101307
Uniprot IDs		O43914 X6RGC9	H9KV29 O00241 Q5TFQ8
PDB IDs		2L34 2L35 4WO1 4WOL	2D9C 2JJU 2JJV
Enriched GO Terms of Interacting Partners?
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