TYROBP and SLC35B4

Data Source:
BioGRID (two hybrid)

		TYROBP	SLC35B4
Description		transmembrane immune signaling adaptor TYROBP	solute carrier family 35 member B4
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Secretory Granule Membrane	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Integral Component Of Golgi Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	UDP-N-acetylglucosamine Transmembrane Transporter Activity UDP-xylose Transmembrane Transporter Activity Protein Binding Transmembrane Transporter Activity
	Biological Process	Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway Stimulatory C-type Lectin Receptor Signaling Pathway Myeloid Leukocyte Activation Microglial Cell Activation Involved In Immune Response Neutrophil Activation Involved In Immune Response Cellular Defense Response Signal Transduction Positive Regulation Of Gene Expression Actin Cytoskeleton Organization Osteoclast Differentiation Negative Regulation Of B Cell Proliferation Forebrain Development Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Negative Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Macrophage Fusion Intracellular Signal Transduction Apoptotic Cell Clearance Neutrophil Degranulation Innate Immune Response Response To Axon Injury Regulation Of Immune Response Protein Stabilization Apoptotic Signaling Pathway Positive Regulation Of Hippocampal Neuron Apoptotic Process Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Neuron Death Positive Regulation Of Receptor Localization To Synapse Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Protein Localization To Cell Surface Positive Regulation Of Osteoclast Development	Regulation Of Gluconeogenesis Carbohydrate Transport UDP-xylose Transmembrane Transport UDP-N-acetylglucosamine Transmembrane Transport
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 interactions DAP12 signaling DAP12 signaling Signal regulatory protein family interactions Other semaphorin interactions Neutrophil degranulation	Transport of nucleotide sugars
Drugs
Diseases		Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); Nasu-Hakola disease
GWAS			Mean platelet volume ( 32888494 27863252) Plateletcrit ( 32888494) Systolic blood pressure response to thiazide and thiazide-like diuretics in hypertension ( 31754133)
Interacting Genes		15 interacting genes: CD300E CLEC5A KIR3DS1 KLRC3 KLRC4 KLRK1 NCR2 SIGLEC14 SIRPB1 SLC35B4 SYK TMEM86A TREM1 TREM2 ZAP70	32 interacting genes: AQP6 CD79A CISD2 CLDN5 CPLX4 CREB3L1 EBAG9 ERGIC3 ERP29 FAM209A FAM210B FFAR2 GPR152 GPX8 HSD17B13 KASH5 LHFPL5 LMNA MMGT1 MUC1 PDZK1IP1 PVR RHBDL2 SCARA5 SLC18A1 STOM TBXA2R TMEM130 TMEM237 TMEM52B TYROBP VSIR
Entrez ID		7305	84912
HPRD ID		04996	11578
Ensembl ID		ENSG00000011600	ENSG00000205060
Uniprot IDs		O43914 X6RGC9	Q969S0
PDB IDs		2L34 2L35 4WO1 4WOL
Enriched GO Terms of Interacting Partners?
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